Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes

• Published in: Gynecologic oncology Vol. 162; no. 3; pp. 741 - 750
• Main Authors: Gadducci, Angiolo, Multinu, Francesco, Cosio, Stefania, Carinelli, Silvestro, Ghioni, Mariacristina, Aletti, Giovanni Damiano
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021
• Subjects: Adenocarcinoma, Clear Cell - diagnosis; Adenocarcinoma, Clear Cell - epidemiology; Adenocarcinoma, Clear Cell - pathology; Adenocarcinoma, Clear Cell - therapy; Biological Factors - therapeutic use; Chemotherapy, Adjuvant - methods; Clear cell carcinoma of the ovary; Cytoreduction Surgical Procedures; Endometriosis - complications; Female; Hematology, Oncology, and Palliative Medicine; Humans; Molecular pathways; Neoplasm Staging; Obstetrics and Gynecology; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - therapy; Pathology; Prognosis; Salpingo-oophorectomy - methods; Surgery; Targeted therapy; Pathology; Molecular pathways; Prognosis; Targeted therapy; Surgery; Clear cell carcinoma of the ovary

Clear cell carcinoma of the ovary is a rare and distinct histotype of epithelial ovarian carcinomas. Women diagnosed with clear cell carcinomas are usually younger and diagnosed at earlier stages than those with the most common high-grade serous histology. Endometriosis is considered a main risk fac...