p53 codon 72 polymorphism and coronary artery disease: evidence of association with left ventricular ejection fraction

• Published in: The American journal of the medical sciences Vol. 343; no. 2; p. 127
• Main Authors: Gloria-Bottini, Fulvia, Saccucci, Patrizia, Magrini, Andrea, Bottini, Egidio, Banci, Maria, Papetti, Federica, Nardi, Paolo, Scognamiglio, Mattia, Pellegrino, Antonio, Chiariello, Luigi
• Format: Journal Article
• Language: English
• Published: United States 01.02.2012
• Subjects: Adult; Aged; Codon - genetics; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; Coronary Artery Disease - physiopathology; Echocardiography; Female; Genes, p53; Humans; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Rome - epidemiology; Stroke Volume
• DOI: 10.1097/MAJ.0b013e318223ac71

Recently, there has been a surge of interest on the possible relationship between p53 polymorphism and coronary atherosclerosis. The authors have investigated the possible association of p53 codon 72 polymorphism with left ventricular ejection fraction (LVEF) in subjects with and without coronary artery disease (CAD). The authors have studied 198 subjects admitted consecutively to Valmontone Hospital for CAD and 129 subjects admitted for cardiovascular diseases without CAD. Fifty-nine subjects admitted for CAD to Division of Cardiac Surgery of Tor Vergata University were also studied. All subjects were from the white population. The p53 polymorphism was evaluated using the restriction fragment length polymorphism polymerase chain reaction. p53 codon 72 polymorphism is a significant independent predictor of LVEF in subjects with CAD but not in subjects with cardiovascular disease without CAD. In subjects with CAD, LVEF is significantly lower in subjects carrying the *Pro variant than in *Arg/*Arg subjects. This effect is more evident in subjects with a positive history of infarction. Our study points to a significant relationship of p53 codon 72 polymorphism with cardiac function in subjects with CAD.