Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

• Published in: Molecular cancer Vol. 16; no. 1; pp. 135 - 14
• Main Authors: Chang, Yu-Chan, Su, Chia-Yi, Chen, Ming-Huang, Chen, Wei-Shone, Chen, Chi-Long, Hsiao, Michael
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.08.2017; BioMed Central; BMC
• Subjects: Analysis; Animals; Cancer metastasis; Cell Line, Tumor; Cell Movement; Colon cancer; Colonic Neoplasms - diagnosis; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Development and progression; Diagnosis; G proteins; Gene expression; Health aspects; Heterografts; Humans; IL-6; Immunohistochemistry; Interleukin-6 - metabolism; Male; Mice; Neoplasm Invasiveness; Prognosis; RAB GTPases; rab3 GTP-Binding Proteins - metabolism; rab3 GTP-Binding Proteins - secretion; RAB3C; STAT3; STAT3 Transcription Factor - metabolism; Illinois; RAB GTPases; RAB3C; Colon cancer; IL-6; STAT3

RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic RABs in colorectal carcinogenesis remain to be elucidated. Immunohistochemistry analysis of...