Dampened STING-Dependent Interferon Activation in Bats

• Published in: Cell Host & Microbe Vol. 23; no. 3; pp. 297 - 301.e4
• Main Authors: Xie, Jiazheng, Li, Yang, Shen, Xurui, Goh, Geraldine, Zhu, Yan, Cui, Jie, Wang, Lin-Fa, Shi, Zheng-Li, Zhou, Peng
• Format: Journal Article Web Resource
• Language: English
• Published: United States Elsevier Inc 14.03.2018; Elsevier BV
• Subjects: Animals; bats; Brief Report; Cell Line; Chiroptera - genetics; Chiroptera - immunology; Chiroptera - virology; Cytoplasm - virology; Cytosol - metabolism; dampened; Disease Reservoirs; DNA Damage; DNA sensing; DNA, Viral - metabolism; DNA-Binding Proteins; Gene Expression; HEK293 Cells; Humans; interferon; Interferons - metabolism; Membrane Proteins - genetics; Membrane Proteins - immunology; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; Mutation; Nuclear Proteins - metabolism; Phosphoproteins - metabolism; Sendai virus; Sequence Analysis, RNA; STING; Toll-Like Receptor 9 - immunology; virus; Virus Diseases - immunology; Virus Diseases - veterinary; bats; STING; dampened; interferon; virus; DNA sensing

Compared with terrestrial mammals, bats have a longer lifespan and greater capacity to co-exist with a variety of viruses. In addition to cytosolic DNA generated by these viral infections, the metabolic demands of flight cause DNA damage and the release of self-DNA into the cytoplasm. However, wheth...