Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword

• Published in: Immunobiology (1979) Vol. 222; no. 1; pp. 89 - 100
• Main Authors: Dajon, Marion, Iribarren, Kristina, Cremer, Isabelle
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier GmbH 01.01.2017
• Subjects: Advanced Basic Science; Allergy and Immunology; Animals; Anti-tumoral effect; Gene Expression Regulation, Neoplastic; Humans; Immune cells; Immunity; Immunomodulation - genetics; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; NF-kappa B - metabolism; Pro-tumoral effect; Signal Transduction; TLR; TLR signaling; Toll-Like Receptors - agonists; Toll-Like Receptors - genetics; Toll-Like Receptors - metabolism; Tumor cells; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; TLR signaling; TLR; Immune cells; Anti-tumoral effect; Tumor cells; Pro-tumoral effect

Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various pathogen- and damage-associated molecular pattern molecules playing an important role in inflammation by activating NF-кB. TLRs, mainly expressed by innate immune cells, are involved in inducing and regulating...