A comprehensive review of oncogenic Notch signaling in multiple myeloma

• Published in: PeerJ (San Francisco, CA) Vol. 12; p. e18485
• Main Author: Roosma, Justin
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 28.11.2024; PeerJ, Inc; PeerJ Inc
• Subjects: Angiogenesis; Antibodies; Antigens; B cells; Bone diseases; Bone marrow; Bone marrow metastasis; Cancer; Cell Biology; Cell proliferation; Chromosomes; Development and progression; Disease resistance; Drug resistance; Epidermal growth factor; Genes; Hematology; Humans; Hypercalcemia; Immunoglobulins; Immunology; Invasiveness; Ligands; Multiple myeloma; Multiple Myeloma - metabolism; Multiple Myeloma - pathology; Mutation; Notch signaling; Pharmacology; Plasma; Plasma cells; Receptors, Notch - genetics; Receptors, Notch - metabolism; Signal Transduction; Tumor Microenvironment; Tumors; United States; United States > US; Cancer genetics; Signal transduction; Cancer biology; Bone marrow metastasis; Precision medicine; Tumor microenvironment; Notch signaling; Leukemia; Multiple myeloma; Plasma cells

Multiple myeloma remains an incurable plasma cell cancer with radical case-by-case heterogeneity. Because of this, personalized and disease-specific biology of multiple myeloma must be understood for the discovery of effective molecular targets. The highly evolutionarily conserved Notch signaling pa...