Estrogen induces stromal cell-derived factor 1 (SDF-1/CXCL12) production in human endometrial stromal cells: a possible role of endometrial epithelial cell growth

• Published in: Fertility and sterility Vol. 95; no. 1; pp. 444 - 447
• Main Authors: Tsutsumi, Akihiro, M.D, Okada, Hidetaka, M.D, Nakamoto, Tsuyoshi, M.D, Okamoto, Rika, M.T, Yasuda, Katsuhiko, M.D, Kanzaki, Hideharu, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2011; Elsevier
• Subjects: acetates; Adult; antagonists; Biological and medical sciences; Cell Communication - drug effects; Cell Communication - physiology; Cell Division - drug effects; Cell Division - physiology; cell growth; Chemokine CXCL12 - metabolism; CXCR4; endometrial stromal cells; endometrium; Endometrium - cytology; epithelial cells; Epithelial Cells - cytology; Epithelial Cells - drug effects; Epithelial Cells - metabolism; estradiol; Estradiol - analogs & derivatives; Estradiol - pharmacology; estrogen; Estrogen Antagonists - pharmacology; estrogen receptors; Estrogens - metabolism; Estrogens - pharmacology; Female; Gynecology. Andrology. Obstetrics; human endometrium; Humans; In Vitro Techniques; Internal Medicine; Medical sciences; medroxyprogesterone; messenger RNA; Middle Aged; Obstetrics and Gynecology; Paracrine Communication - drug effects; Paracrine Communication - physiology; SDF-1 (CXCL12); stromal cells; Stromal Cells - cytology; Stromal Cells - drug effects; Stromal Cells - metabolism; endometrial stromal cells; CXCR4; estrogen; SDF-1 (CXCL12); human endometrium; Human; Cell proliferation; Gynecology; Estrogen; Biosynthesis; Obstetrics; Stromal cell derived factor 1; Epithelial cell; Stromal cell; Endometrium; CXCR4 chemokine receptor

Estradiol enhanced stromal cell-derived factor 1 (SDF-1/CXCL12) production levels in human endometrial stromal cells (ESCs) in a time- and dose-dependent manner that could be completely abolished by ICI 182,780 (estrogen receptor antagonist) and medroxyprogesterone acetate. Although SDF-1 was undete...