Acute blood glucose fluctuation enhances rat aorta endothelial cell apoptosis, oxidative stress and pro-inflammatory cytokine expression in vivo

• Published in: Cardiovascular diabetology Vol. 15; no. 1; p. 109
• Main Authors: Wu, Na, Shen, Haitao, Liu, Henan, Wang, Yanjun, Bai, Yu, Han, Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central 05.08.2016
• Subjects: Acute Disease; Animals; Apoptosis - physiology; Biomarkers - blood; Blood Glucose - physiology; Diet, High-Fat; Disease Models, Animal; Endothelial Cells - metabolism; Inflammation - metabolism; Male; Original Investigation; Oxidative Stress - physiology; Rats, Wistar; Oxidative stress; Inflammation; Endothelial cells; Acute blood glucose fluctuation; Apoptosis

Complications of diabetes mellitus (DM) are related not only to elevated plasma glucose, but also plasma glucose fluctuations. However, the specific mechanism underlying the role of plasma glucose fluctuation in the pathogenesis of DM complications remains poorly understood. In the present study, th...