Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase

• Published in: The Journal of biological chemistry Vol. 285; no. 43; pp. 33037 - 33044
• Main Authors: Bélanger, François, Stepinski, Janusz, Darzynkiewicz, Edward, Pelletier, Jerry
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.10.2010; American Society for Biochemistry and Molecular Biology
• Subjects: CAP1; Catalysis; HeLa Cells; Humans; Methylation; Methyltransferases - chemistry; Methyltransferases - genetics; Methyltransferases - metabolism; mRNA; mRNA cap; Ribose - chemistry; Ribose - genetics; Ribose - metabolism; RNA; RNA Caps - chemistry; RNA Caps - genetics; RNA Caps - metabolism; RNA Methylation; RNA Methyltransferase; RNA Modification; CAP1; RNA; RNA Methylation; RNA Methyltransferase; RNA Modification; mRNA cap; mRNA

Cellular eukaryotic mRNAs are capped at their 5′ ends with a 7-methylguanosine nucleotide, a structural feature that has been shown to be important for conferring mRNA stability, stimulating mRNA biogenesis (splicing, poly(A) addition, nucleocytoplasmic transport), and increasing translational effic...