Frontal Hyperconnectivity Related to Discounting and Reversal Learning in Cocaine Subjects

• Published in: Biological psychiatry (1969) Vol. 69; no. 11; pp. 1117 - 1123
• Main Authors: Camchong, Jazmin, MacDonald, Angus W., Nelson, Brent, Bell, Christopher, Mueller, Bryon A., Specker, Sheila, Lim, Kelvin O.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2011
• Subjects: Adult; Anterior cingulate; Brain Mapping; cocaine; Cocaine-Related Disorders - physiopathology; delayed discount; Female; frontal; Frontal Lobe - physiopathology; functional connectivity; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net - physiopathology; Neuropsychological Tests; Psychiatric/Mental Health; reversal learning; Reversal Learning - physiology; Theory of Mind - physiology; frontal; reversal learning; Anterior cingulate; functional connectivity; cocaine; delayed discount

Functional neuroimaging studies suggest that chronic cocaine use is associated with frontal lobe abnormalities. Functional connectivity (FC) alterations of cocaine-dependent individuals (CD), however, are not yet clear. This is the first study to our knowledge that examines resting FC of anterior ci...