Early and multiple origins of metastatic lineages within primary tumors

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 8; pp. 2140 - 2145
• Main Authors: Zhao, Zi-Ming, Zhao, Bixiao, Bai, Yalai, Iamarino, Atila, Gaffney, Stephen G., Schlessinger, Joseph, Lifton, Richard P., Rimm, David L., Townsend, Jeffrey P.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.02.2016; National Acad Sciences
• Subjects: Biological Sciences; Cancer; Cell Lineage - genetics; Cell Transformation, Neoplastic - genetics; Evolution, Molecular; Female; Genetic Variation; Humans; Likelihood Functions; Male; Metastasis; Models, Genetic; Mutation; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Neoplasms - genetics; Neoplasms - pathology; Oncogenes; Phylogenetics; Phylogeny; Time Factors; Tumors; oncogenes; ancestral reconstruction; chronograms; cancer; tumor phylogenetics

Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such as the divergence times and genetic clonality of metastatic lineages. To address these challenges, we performed tumor phylogenetics using mole...