Early and multiple origins of metastatic lineages within primary tumors - Zhao, Zi-Ming; Zhao, Bixiao; Bai, Yalai; Iamarino, Atila; Gaffney, Stephen G.; Schlessinger, Joseph; Lifton, Richard P.; Rimm, David L.; Townsend, Jeffrey P. (Proceedings of the National Academy of Sciences - PNAS, 2016)
Keywords: Biological Sciences; Cancer; Cell Lineage - genetics; Cell Transformation, Neoplastic - genetics; Evolution, Molecular; Female; Genetic Variation; Humans; Likelihood Functions; Male; Metastasis; Models, Genetic; Mutation; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Neoplasms - genetics; Neoplasms - pathology; Oncogenes; Phylogenetics; Phylogeny; Time Factors; Tumors; oncogenes; ancestral reconstruction; chronograms; cancer; tumor phylogenetics