Reperfusion injury protection during Basic Life Support improves circulation and survival outcomes in a porcine model of prolonged cardiac arrest

• Published in: Resuscitation Vol. 105; pp. 29 - 35
• Main Authors: Debaty, Guillaume, Lurie, Keith, Metzger, Anja, Lick, Michael, Bartos, Jason A., Rees, Jennifer N., McKnite, Scott, Puertas, Laura, Pepe, Paul, Fowler, Raymond, Yannopoulos, Demetris
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2016; Elsevier
• Subjects: Active compression decompression; Animals; Basic life support; Blood Circulation; Cardiac arrest; Cardiology and cardiovascular system; Cardiopulmonary resuscitation; Cardiopulmonary Resuscitation - methods; Cardiopulmonary Resuscitation - mortality; Disease Models, Animal; Electric Countershock - methods; Emergency; Epinephrine - administration & dosage; Female; Heart Arrest - mortality; Heart Arrest - therapy; Human health and pathology; Impedance threshold device; Ischemic postconditioning; Ischemic Postconditioning - methods; Life Sciences; Prospective Studies; Random Allocation; Reperfusion Injury - prevention & control; Swine; Sympathomimetics - administration & dosage; Time Factors; Impedance threshold device; Basic life support; Ischemic postconditioning; Cardiopulmonary resuscitation; Cardiac arrest; Active compression decompression

Ischemic postconditioning (PC) using three intentional pauses at the start of cardiopulmonary resuscitation (CPR) improves outcomes after cardiac arrest in pigs when epinephrine (epi) is used before defibrillation. We hypothesized PC, performed during basic life support (BLS) in the absence of epine...