Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

• Published in: Journal of antimicrobial chemotherapy Vol. 67; no. 2; pp. 452 - 459
• Main Authors: YOUSEF, Jumana M, GONG CHEN, HILL, Prue A, NATIONAL, Roger L, JIAN LI
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2012; Oxford Publishing Limited (England)
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Apoptosis; Ascorbic Acid - administration & dosage; Ascorbic Acid - pharmacology; Bacterial infections; Biological and medical sciences; Cells, Cultured; Colistin - administration & dosage; Colistin - adverse effects; Colistin - pharmacokinetics; Injections, Intravenous; Kidney Diseases - chemically induced; Kidney Diseases - prevention & control; Kidneys; Male; Medical sciences; Original Research; Pharmacology; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; Rodents; Vitamin C; Vitamins - administration & dosage; Vitamins - pharmacology; rat kidney tubular cells; Ascorbic acid; Urinary system disease; Colistin; Rat; Cyclic peptides; Toxicity; vitamin C; Rodentia; Vitamin; polymyxin E; In vitro; Kidney; Prevention; Vertebrata; Antibiotic; Mammalia; Polypeptide; Cell death; Animal; Antibacterial agent; Pharmacokinetics; Cell; Apoptosis

The use of colistin in the treatment of life-threatening Gram-negative infections is associated with a high rate of nephrotoxicity that is dose limiting. This study aimed to examine the nephroprotective effect of ascorbic acid against colistin-induced nephrotoxicity. Rats were treated intravenously...