Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

• Published in: Molecular neurodegeneration Vol. 14; no. 1; pp. 29 - 14
• Main Authors: Meade, Richard M., Fairlie, David P., Mason, Jody M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.07.2019; BioMed Central; BMC
• Subjects: Alpha-synuclein; alpha-Synuclein - metabolism; Amyloid; Brain - pathology; Care and treatment; CryoEM; Development and progression; Humans; Lewy Bodies - metabolism; Lewy Body Disease - metabolism; Membrane proteins; Multiple system atrophy; Multiple System Atrophy - metabolism; Multiple System Atrophy - pathology; Nuclear magnetic resonance; Oligomers; Parkinson disease; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson’s disease; Phenotypes; Protein-protein interactions; Review; Oligomers; Amyloid; Alpha-synuclein; CryoEM; Parkinson’s disease; Protein-protein interactions

Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). All diseases are determined by αS aggregate deposition but can be separated...