A single nucleotide change in a core promoter is involved in the progressive overexpression of the duplicated CYP9M10 haplotype lineage in Culex quinquefasciatus

• Published in: Insect biochemistry and molecular biology Vol. 66; pp. 96 - 102
• Main Authors: Itokawa, Kentaro, Komagata, Osamu, Kasai, Shinji, Tomita, Takashi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2015
• Subjects: Animals; Core promoter; Culex - drug effects; Culex - enzymology; Culex - genetics; Culex quinquefasciatus; cytochrome P-450; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; DNA; Gene Duplication; Gene Expression; gene overexpression; genes; Genes, Insect; Haplotypes; Insecticide resistance; Insecticide Resistance - genetics; Insecticides; Mutation; Phylogeny; Polymorphism, Single Nucleotide; Pyrethrins; Regulatory mutation; sequence homology; Sequence Homology, Nucleic Acid; TATA Box; transcription (genetics); transposons; TATA-box; Regulatory mutation; Insecticide resistance; Core promoter; Cytochrome P450

Although the importance of cis-acting mutations on detoxification enzyme genes for insecticide resistance is widely accepted, only a few of them have been determined as concrete mutations present in genomic DNA till date. The overexpression of a cytochrome P450 gene, CYP9M10, is associated with pyre...