Ketamine’s effect on inflammation and kynurenine pathway in depression: A systematic review

• Published in: Journal of psychopharmacology (Oxford) Vol. 35; no. 8; pp. 934 - 945
• Main Authors: Kopra, Emma, Mondelli, Valeria, Pariante, Carmine, Nikkheslat, Naghmeh
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2021
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Antidepressive Agents - pharmacology; Bipolar Disorder - drug therapy; Cytokines - metabolism; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - physiopathology; Humans; Inflammation - drug therapy; Inflammation - pathology; Ketamine - pharmacology; Kynurenine - metabolism; Tryptophan - metabolism; cytokine; kynurenine; Ketamine; depression; inflammation

Background: Ketamine is a novel rapid-acting antidepressant with high efficacy in treatment-resistant patients. Its exact therapeutic mechanisms of action are unclear; however, in recent years its anti-inflammatory properties and subsequent downstream effects on tryptophan (TRP) metabolism have spar...