Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 312; no. 3; pp. H375 - H383
• Main Authors: Toba, Hiroe, Cannon, Presley L., Yabluchanskiy, Andriy, Iyer, Rugmani Padmanabhan, D’Armiento, Jeanine, Lindsey, Merry L.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2017
• Series: Advances in Cardiovascular Geroscience
• Subjects: Aging; Aging - pathology; Animals; Blood Vessels - physiopathology; Cardiomegaly - diagnostic imaging; Cardiomegaly - genetics; Cardiomegaly - physiopathology; Cardiovascular disease; Cell Size; Collagen - metabolism; Echocardiography; Enzymes; Female; Fibrosis; Genes; Genotype & phenotype; Heart Ventricles - pathology; Humans; Inflammation - physiopathology; Macrophages; Male; Matrix Metalloproteinase 9 - genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac - pathology; Risk factors; aging; inflammation; MMP-9; heart

Advancing age is an independent risk factor for cardiovascular disease. Matrix metalloproteinase-9 (MMP-9) is secreted by macrophages and robustly increases in the left ventricle (LV) with age. The present study investigated the effect of MMP-9 overexpression in macrophages on cardiac aging. We comp...