Analyzing Schizophrenia by DNA Microarrays

• Published in: Biological psychiatry (1969) Vol. 69; no. 2; pp. 157 - 162
• Main Authors: Horváth, Szatmár, Janka, Zoltán, Mirnics, Károly
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2011
• Subjects: Autopsy; Brain - metabolism; Brain - physiopathology; Brain Chemistry - genetics; DNA microarrays; gene expression; Gene Expression Profiling; Humans; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neuropsychiatry - methods; Oligonucleotide Array Sequence Analysis; postmortem; Postmortem Changes; Psychiatry; RNA-seq; schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenia - physiopathology; transcriptome; DNA microarrays; schizophrenia; RNA-seq; postmortem; transcriptome; gene expression

To understand the pathological processes of schizophrenia, we must embrace the analysis of the diseased human brain: we will never be able to recapitulate the pathology of uniquely human disorders in an animal model. Based on the outcome of the transcriptome profiling experiments performed to date,...