LncRNA NEAT1 Promotes the Malignant Progression of Colorectal Cancer by Targeting ZEB1 via miR-448

• Published in: Technology in cancer research & treatment Vol. 21; p. 15330338221085348
• Main Authors: Wu, Hanquan, Dong, Dengwen, Wang, Jiwei, Yin, Shiwen, Gong, Yuanxiang, Yang, Chao, Bai, Yihan, Wang, Junyi, Du, Yanhong
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2022; Sage Publications Ltd; SAGE Publishing
• Subjects: Animals; Apoptosis - genetics; Bioinformatics; Cancer; Carcinogenesis - genetics; Cell Line, Tumor; Cell Proliferation - genetics; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Gene Expression Regulation, Neoplastic; Humans; Metastases; Mice; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; Non-coding RNA; Original; Polymerase chain reaction; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Tumorigenesis; Western blotting; Zinc Finger E-box-Binding Homeobox 1 - genetics; Zinc Finger E-box-Binding Homeobox 1 - metabolism; LncRNA NEAT1; colorectal cancer; ZEB1; miR-448

Background: Long noncoding RNAs have been associated with various types of malignant tumors; however, the specific role of long noncoding RNAs in tumorigenesis still remains unclear in colorectal cancer. Here, we aim to elucidate the role of long noncoding RNA nuclear paraspeckle assembly transcript...