Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: Dose-dependent effects in the human photosensitivity model - Kasteleijn- Nolst Trenité, Dorothée; Parain, Dominique; Genton, Pierre; Masnou, Pascal; Schwartz, Jean-Charles; Hirsch, Edouard (Epilepsy & behavior, 2013)
Keywords: Administration, Oral; Adult; Animals; Anticonvulsants - pharmacokinetics; Anticonvulsants - therapeutic use; BF2.649; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electroshock - adverse effects; Electroshock - classification; Epilepsy; Epilepsy, Reflex - drug therapy; Epilepsy, Reflex - etiology; Excitatory Amino Acid Agonists - toxicity; Female; H3R; Histamine 3 antagonist; Humans; Kainic Acid - toxicity; Male; Mice; Neurology; Nonimidazole; Photosensitivity model; Piperidines - pharmacokinetics; Piperidines - therapeutic use; Pitolisant; PPR; Proof of concept; Time Factors; Tiprolisant; Young Adult; PPR; Tiprolisant; Photosensitivity model; H3R; Epilepsy; Histamine 3 antagonist; Pitolisant; Nonimidazole; BF2.649; Proof of concept