Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population

• Published in: BMC neurology Vol. 19; no. 1; pp. 291 - 12
• Main Authors: Zhao, Lei, Fang, Jinghuan, Zhou, Muke, Zhou, Jie, Yu, Lihua, Chen, Ning, He, Li
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.11.2019; BioMed Central; BMC
• Subjects: Aged; Asian Continental Ancestry Group - genetics; Atherosclerosis; Atherosclerosis - enzymology; Atherosclerosis - genetics; Brain Ischemia - enzymology; Brain Ischemia - genetics; Case-Control Studies; Chromosomes; COX-1; COX-2; COX-2 inhibitors; Cyclooxygenase 1 - genetics; Cyclooxygenase 2 - genetics; Disease susceptibility; Female; Gene-gene; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease - genetics; Genotype; Humans; Interaction; Ischemia; Ischemic stroke; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk factors; Single nucleotide polymorphism; Single nucleotide polymorphisms; Stroke; Stroke - enzymology; Stroke - genetics; China; Ischemic stroke; Single nucleotide polymorphism; COX-2; COX-1; Interaction; Gene-gene

Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility of ischemic stroke. We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes in order to explaining the association between these polymorphisms and we also investigated the associa...