Neutrophils from severe asthmatic patients induce epithelial to mesenchymal transition in healthy bronchial epithelial cells

• Published in: Respiratory research Vol. 20; no. 1; pp. 234 - 14
• Main Authors: Haddad, Alexandre, Gaudet, Mellissa, Plesa, Maria, Allakhverdi, Zoulfia, Mogas, Andrea K., Audusseau, Severine, Baglole, Carolyn J., Eidelman, David H., Olivenstein, Ronald, Ludwig, Mara S., Hamid, Qutayba
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.10.2019; BioMed Central; BMC
• Subjects: Adult; Airway remodeling; Asthma; Asthma - metabolism; Asthma - pathology; Bronchi - cytology; Bronchi - metabolism; Care and treatment; Cells, Cultured; Coculture Techniques - methods; Culture Media, Conditioned - pharmacology; Development and progression; Epithelial-mesenchymal transition; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - physiology; Female; Gene expression; Genetic aspects; Health aspects; Humans; Male; Middle Aged; Neutrophils; Neutrophils - metabolism; Respiratory Mucosa - metabolism; Severe asthma; Severity of Illness Index; TGF-β1; Transforming growth factors; Canada; Epithelial-mesenchymal transition; TGF-β1; Airway remodeling; Severe asthma; Neutrophils

Asthma is a heterogenous disease characterized by chronic inflammation and airway remodeling. An increase in the severity of airway remodeling is associated with a more severe form of asthma. There is increasing interest in the epithelial to mesenchymal transition process and mechanisms involved in...