Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family

• Published in: Nature genetics Vol. 37; no. 5; pp. 514 - 519
• Main Authors: van Dijk, Marie, Mulders, Joyce, Poutsma, Ankie, Könst, Andrea A M, Lachmeijer, Augusta M A, Dekker, Gustaaf A, Blankenstein, Marinus A, Oudejans, Cees B M
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2005; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chromosomes, Human, Pair 10; Classical genetics, quantitative genetics, hybrids; Deoxyribonucleic acid; Diseases of mother, fetus and pregnancy; DNA; DNA binding proteins; Epigenetics; Female; Females; Forkhead Transcription Factors; Fundamental and applied biological sciences. Psychology; Gene Function; Genes; Genetic aspects; Genetic variation; Genetics of eukaryotes. Biological and molecular evolution; Gynecology. Andrology. Obstetrics; Haplotypes; Human Genetics; Humans; Inactivation; letter; Male; Medical sciences; Methods, theories and miscellaneous; Molecular Sequence Data; Multigene Family; Mutation; Pedigree; Physiological aspects; Placenta; Pre-Eclampsia - genetics; Preeclampsia; Pregnancy; Pregnancy. Fetus. Placenta; Proteins; Risk factors; Sequence Analysis, DNA; Trans-Activators - genetics; Netherlands; Finland; Genetic mapping; Origin; Wing; Protein kinase B; Pregnancy disorders; Fetal membrane; Segregation; Critical region; Maternal diseases; Pregnancy toxemia; Gene; Analysis; Preeclampsia; Epigenetics; Multigene family; Maternal effect; Inheritance(genetics); Locus

Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Epigenetic inheritance is involved in some populations. By sequence analysis of 17 genes in the 10q22 region with maternal effects, we narrowed the minimal critical region linked with preeclampsia in the Neth...