Transketolase counteracts oxidative stress to drive cancer development - Xu, Iris Ming-Jing; Lai, Robin Kit-Ho; Lin, Shu-Hai; Tse, Aki Pui-Wah; Chiu, David Kung-Chun; Koh, Hui-Yu; Law, Cheuk-Ting; Wong, Chun-Ming; Cai, Zongwei; Wong, Carmen Chak-Lui; Ng, Irene Oi-Lin (Proceedings of the National Academy of Sciences - PNAS, 2016)
Keywords: Animals; Antioxidants; Base Sequence; Biological Sciences; Cancer; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - pathology; Cell Cycle Checkpoints - drug effects; Cell Death - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Cells; Female; Gene Knockdown Techniques; Glucose - metabolism; Glutathione - metabolism; Glycolysis - drug effects; Homeostasis; Humans; Liver Neoplasms - enzymology; Liver Neoplasms - pathology; Male; Metabolome - drug effects; Mice, Nude; Molecular Sequence Data; Niacinamide - analogs & derivatives; Niacinamide - pharmacology; Oxidative stress; Oxidative Stress - drug effects; Pentose Phosphate Pathway - drug effects; Peroxides - pharmacology; Phenylurea Compounds - pharmacology; PNAS Plus; Proteins; Reactive Oxygen Species - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sorafenib; Transketolase - antagonists & inhibitors; Transketolase - genetics; Transketolase - metabolism; Up-Regulation - drug effects; PPP; HCC; metabolism; TKT; ROS