Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks

• Published in: BioMed research international Vol. 2016; no. 2016; pp. 1 - 12
• Main Authors: Chakraborty, Sandip, Alvarez-Ponce, David
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc
• Subjects: Adaptation; Analysis; Animals; Drosophila melanogaster - genetics; Drosophila Proteins - genetics; Evolution & development; Gene expression; Genes; Genetic aspects; Genomes; Humans; Insects; Mammals; Metabolism; Mutation; Natural selection; Organisms; Protein Interaction Maps - genetics; Protein-protein interactions; Proteins; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins - genetics; Selection, Genetic - genetics; Studies; Trends; Yeast

Proteins within a molecular network are expected to be subject to different selective pressures depending on their relative hierarchical positions. However, it is not obvious what genes within a network should be more likely to evolve under positive selection. On one hand, only mutations at genes wi...