Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial

• Published in: The American journal of clinical nutrition Vol. 101; no. 5; pp. 914 - 921
• Main Authors: Dower, James I, Geleijnse, Johanna M, Gijsbers, Lieke, Zock, Peter L, Kromhout, Daan, Hollman, Peter CH
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition 01.05.2015; American Society for Clinical Nutrition, Inc
• Subjects: Adult; Aged; Aged, 80 and over; blood glucose; blood lipids; Blood Pressure - drug effects; Cacao - chemistry; cardioprotective effect; Cardiovascular disease; cardiovascular diseases; Cardiovascular Diseases - prevention & control; Catechin - administration & dosage; catechin contents; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Clinical trials; Cocoa; cohort studies; Cross-Over Studies; dark chocolate; Double-Blind Method; endothelial function; Endothelin-1 - blood; Endothelium, Vascular - drug effects; epicatechin; fasting; Female; flavanol-rich cocoa; foods; Healthy Volunteers; homeostasis; homeostasis model assessment; Humans; hypertensive subjects; insulin; Insulin - blood; Insulin Resistance; Male; men; Metabolites; Middle Aged; nitric oxide; Nitric Oxide - blood; Nutrition research; placebos; plasma epicatechin; Polyphenols; quercetin; Quercetin - administration & dosage; Quercetin - analogs & derivatives; reduces blood-pressure; risk factors; screening; systolic blood pressure; Tea; Tea - chemistry; Triglycerides - blood; Vascular Stiffness - drug effects; women; CVD; clinical trial; tea; vascular function; epicatechin; quercetin; flow-mediated dilation; flavonoids; insulin resistance; cocoa
• ISSN: 0002-9165; 1938-3207; 1938-3207
• DOI: 10.3945/ajcn.114.098590

Background: Prospective cohort studies showed inverse associations between the intake of flavonoid-rich foods (cocoa and tea) and cardiovascular disease (CVD). Intervention studies showed protective effects on intermediate markers of CVD. This may be due to the protective effects of the flavonoids e...