Latent tuberculosis infection – Revisiting and revising concepts

• Published in: Tuberculosis (Edinburgh, Scotland) Vol. 95; no. 4; pp. 373 - 384
• Main Authors: Salgame, Padmini, Geadas, Carolina, Collins, Lauren, Jones-López, Edward, Ellner, Jerrold J.
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.07.2015
• Subjects: Biomarkers; Biomarkers - metabolism; Diagnosis; Disease Progression; Host-Pathogen Interactions; Humans; Infectious Disease; Interferon-gamma Release Tests; Latent Tuberculosis - diagnosis; Latent Tuberculosis - immunology; Latent Tuberculosis - microbiology; Latent Tuberculosis - therapy; Latent tuberculosis infection; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - pathogenicity; Predictive Value of Tests; Prognosis; Progression; Pulmonary/Respiratory; Risk Factors; Tuberculin Test; Tuberculosis Vaccines - therapeutic use; Virulence; Progression; Biomarkers; Diagnosis; Latent tuberculosis infection

Host- and pathogen-specific factors interplay with the environment in a complex fashion to determine the outcome of infection with Mycobacterium tuberculosis (Mtb), resulting in one of three possible outcomes: cure, latency or active disease. Although much remains unknown about its pathophysiology,...