Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture

• Published in: Biological trace element research Vol. 167; no. 2; pp. 179 - 186
• Main Authors: Aydemir, Birsen, Akdemir, Ramazan, Vatan, M. Bulent, Cinemre, F. Behice, Cinemre, Hakan, Kiziler, Ali Riza, Bahtiyar, Nurten, Buyukokuroglu, M. Emin, Gurol, Gonul, Ogut, Selim
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2015; Springer Nature B.V
• Subjects: Adult; angiogenesis; antioxidants; Biochemistry; Biomedical and Life Sciences; Biotechnology; connective tissues; Cytokines - blood; echocardiography; etiology; Female; glutathione; heart valve diseases; Humans; Inflammation; interleukin-1beta; interleukin-6; interleukin-8; interleukins; Life Sciences; Male; Middle Aged; Mitral Valve Insufficiency - blood; Nerve Growth Factors - blood; Nutrition; Oncology; Oxidative stress; pathogenesis; patients; platelet-derived growth factor; Rupture, Spontaneous - blood; Selenium; Selenium - blood; Studies; Trace elements; tumor necrosis factor-alpha; vascular endothelial growth factor A; Vascular Endothelial Growth Factor A - blood; Zinc; Zinc - blood; Reduced glutathione; Chordae tendineae rupture; Angiogenesis; Inflammation; Selenium; Midkine; Zinc
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-015-0307-6

Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-α, IL-1β, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.