A double dealing tale of p63: an oncogene or a tumor suppressor

• Published in: Cellular and molecular life sciences : CMLS Vol. 75; no. 6; pp. 965 - 973
• Main Authors: Chen, Yonglong, Peng, Yougong, Fan, Shijie, Li, Yimin, Xiao, Zhi-Xiong, Li, Chenghua
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2018; Springer Nature B.V
• Subjects: Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer; carcinogenesis; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Biology; Cell culture; Cell growth; Cell Proliferation; Cell Survival; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Gene Expression Regulation, Neoplastic; Genes; genetic models; Humans; Isoforms; Life Sciences; loci; Metastases; Metastasis; Molecular modelling; neoplasms; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Oncogenes; p53 Protein; patients; Phosphoproteins - genetics; Phosphoproteins - metabolism; Protein Isoforms - genetics; Protein Isoforms - metabolism; Review; Signal Transduction; Survival; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor suppressor genes; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Tumorigenesis; Tumors; ΔNp63; Cell senescence; TAp63; Cell migration; Oncoprotein

As a member of tumor suppressor p53 family, p63, a gene encoding versatile protein variant, has been documented to correlate with cancer formation and progression, though it is rarely mutated in cancer patients. However, it has long been controversial on whether p63 is an oncogene or a tumor suppres...