Application of Metagenomics Next-Generation Sequencing on Diagnosis of Disseminated Infection Caused by Rhizomucor pusillus in an Acute Lymphoblastic Leukemia Patient

• Published in: Infection and drug resistance Vol. 17; pp. 5707 - 5713
• Main Authors: Chen, Hengxin, Qiu, Mingjin, Xu, Hongxu, Guo, Penghao, Peng, Yaqin
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2024; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Acute lymphoblastic leukemia; Acute lymphocytic leukemia; Amphotericin B; Antibiotics; Antifungal agents; Antiparasitic agents; B cells; Blood; Bone marrow; Bronchus; Case Report; Caspofungin; Chemotherapy; China; Development and progression; Diabetes; Diagnosis; Disseminated infection; Fever; Fungal infections; Fungi; Hematology; Imipenem; Inflammation; Lavage; Leukemia; Lymphatic leukemia; Metagenomics; metagenomics next-generation sequencing; Mortality; Mucormycosis; Next-generation sequencing; Pathogens; Patients; Pleural effusion; Posaconazole; Proteins; Rhizomucor pusillus; Serology; Stem cells; Type 2 diabetes; China; metagenomics next-generation sequencing; diagnosis; Rhizomucor pusillus; disseminated infection

is one of the major pathogens in mucormycosis. Infection due to is rare and has a high mortality rate, especially disseminated mucormycosis infections. Rapid and accurate pathogen identification is important for the development of targeted antifungal therapies. We presented a case of disseminated in...