Innate Immune Receptors: Key Regulators of Metabolic Disease Progression

• Published in: Cell metabolism Vol. 17; no. 6; pp. 873 - 882
• Main Authors: Jin, Chengcheng, Henao-Mejia, Jorge, Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.06.2013
• Subjects: atherosclerosis; Atherosclerosis - immunology; Atherosclerosis - metabolism; Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - metabolism; disease course; Disease Progression; fatty liver; Fatty Liver - immunology; Fatty Liver - metabolism; Humans; Immunity, Innate; immunologic receptors; Inflammation - immunology; innate immunity; insulin resistance; Insulin Resistance - immunology; intestinal microorganisms; Intestines - immunology; Intestines - microbiology; Metabolic Diseases - immunology; metabolism; Non-alcoholic Fatty Liver Disease; noninsulin-dependent diabetes mellitus; obesity; Obesity - immunology; Obesity - metabolism; Receptors, Immunologic - immunology

The study of the intersection of immunology and metabolism is a growing field fueled by the increased prevalence of obesity-associated pathologies. Importantly, the capacity of the innate immune system to sense metabolic stress induced by nutritional surplus has been linked with the progression of o...