Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme

• Published in: Molecular cancer Vol. 17; no. 1; pp. 74 - 7
• Main Authors: Tan, Sze Kiat, Pastori, Chiara, Penas, Clara, Komotar, Ricardo J., Ivan, Michael E., Wahlestedt, Claes, Ayad, Nagi G.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.03.2018; BioMed Central; BMC
• Subjects: Analysis; Antisense RNA; Biological markers; Biomarker; Biomarkers, Tumor; Brain Neoplasms - blood; Brain Neoplasms - diagnosis; Brain Neoplasms - genetics; Brain Neoplasms - mortality; Cancer; Care and treatment; Cell-Free Nucleic Acids; Chemotherapy; Diagnosis; Exosomes; Gene expression; Glioblastoma; Glioblastoma - blood; Glioblastoma - diagnosis; Glioblastoma - genetics; Glioblastoma - mortality; Glioblastomas; HOTAIR; Humans; Letter to the Editor; Long noncoding RNA; Prognosis; Radiotherapy; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; ROC Curve; HOTAIR; Biomarker; Long noncoding RNA; Glioblastoma; Cancer
• ISSN: 1476-4598; 1476-4598
• DOI: 10.1186/s12943-018-0822-0

Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and chemotherapy, the median survival rate is approximately 14 months. Although experimental therapies are in clinical trials for GBM, there is an...