Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma

• Published in: Radiation oncology (London, England) Vol. 14; no. 1; p. 147
• Main Authors: Jia, Angela Y, Narang, Amol, Safar, Bashar, Zaheer, Atif, Murphy, Adrian, Azad, Nilofer S, Gearhart, Susan, Fang, Sandy, Efron, Jonathan, Warczynski, Tam, Hacker-Prietz, Amy, Meyer, Jeffrey
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.08.2019; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adenocarcinoma - pathology; Adenocarcinoma - therapy; Adjuvant chemotherapy; Adult; Aged; Analysis; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cancer treatment; Capecitabine - administration & dosage; Care and treatment; Chemoradiotherapy, Adjuvant - methods; Chemotherapy; Colorectal cancer; Female; Fluorouracil - administration & dosage; Gastrointestinal diseases; Humans; Leucovorin - administration & dosage; Male; Middle Aged; Neoadjuvant Therapy - methods; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Oxaliplatin - administration & dosage; Proctitis; Radiation (Physics); Radiotherapy; Rectal cancer; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; Retrospective Studies; Short-course chemoradiotherapy; Surgery; Toxicity; Treatment Outcome; Tumors; Watch and wait; Short-course chemoradiotherapy; Rectal cancer; Watch and wait

There is continued debate regarding the optimal combinations of radiation therapy and chemotherapy in the preoperative treatment of locally advanced rectal adenocarcinomas. We report our single-institution experience of feasibility and early oncologic outcomes of short-course preoperative radiation...