Statistical analysis for genome-wide association study

• Published in: Journal of biomedical research Vol. 29; no. 4; pp. 285 - 297
• Main Authors: Zeng, Ping, Zhao, Yang, Qian, Cheng, Zhang, Liwei, Zhang, Ruyang, Gou, Jianwei, Liu, Jin, Liu, Liya, Chen, Feng
• Format: Journal Article
• Language: English
• Published: China Editorial Department of Journal of Biomedical Research 01.01.2015
• Subjects: Review; 人口结构; 全基因组; 关联分析; 发病机制; 复杂疾病; 数据质量控制; 统计分析; 队列分析; genetic model; copy number variation; population structure; quality control; multiple comparison; genome-wide association study; meta-analysis; statistical model; missing heritability

In the past few years, genome-wide association study （GWAS） has made great successes in identifying genetic susceptibility loci underlying many complex diseases and traits. The findings provide important genetic insights into understanding pathogenesis of diseases. In this paper, we present an overv...