Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2

• Published in: iScience Vol. 26; no. 11; p. 108254
• Main Authors: Wang, Qian, Li, Zhiteng, Guo, Yicheng, Mellis, Ian A., Iketani, Sho, Liu, Michael, Yu, Jian, Valdez, Riccardo, Lauring, Adam S., Sheng, Zizhang, Gordon, Aubree, Liu, Lihong, Ho, David D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.11.2023; Elsevier
• Subjects: antibody evasion; BA.2.75 subvariants; convergent evolution; evolutionary trajectories; mRNA vaccine; neutralizing monoclonal antibody; receptor-binding affinity; SARS-CoV-2; BA.2.75 subvariants; SARS-CoV-2; convergent evolution; neutralizing monoclonal antibody; antibody evasion; evolutionary trajectories; receptor-binding affinity; mRNA vaccine

SARS-CoV-2 Omicron BA.2.75 has diversified into multiple subvariants with additional spike mutations and several are expanding in prevalence, particularly CH.1.1 and BN.1. Here, we investigated the viral receptor affinities and neutralization evasion properties of major BA.2.75 subvariants actively...