Application of Lipidomics for Assessing Tissue Lipid Profiles of Patients With Squamous Cell Carcinoma

• Published in: Technology in cancer research & treatment Vol. 20; p. 15330338211049903
• Main Authors: Zeng, Weibiao, Zheng, Wen, Hu, Sheng, Zhang, Jianyong, Zhang, Wenxiong, Xu, Jianjun, Yu, Dongliang, Peng, Jinhua, Zhang, Lu, Gong, Meng, Wei, Yiping
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Diglycerides; Discriminant analysis; Genomes; Glycosylphosphatidylinositol; Humans; Linoleic acid; Lipid metabolism; Lipidomics - methods; Lipids; Lipids - analysis; Liquid chromatography; Lung cancer; Lymph nodes; Lymphatic Metastasis - pathology; Male; Mass Spectrometry - methods; Mass spectroscopy; Metabolic Networks and Pathways; Metabolic pathways; Metabolism; Metabolites; Metastases; Middle Aged; Original; Phosphatidylinositol; ROC Curve; Sphingomyelin; Squamous cell carcinoma; Tumors; mass spectrometry; non-small-cell lung carcinoma; lipidomics; lipid metabolism; squamous cell carcinoma

Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles of 40 patients with SqCC. Methods: Lipidomics, based on ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-...