Application of Lipidomics for Assessing Tissue Lipid Profiles of Patients With Squamous Cell Carcinoma
Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles of 40 patients with SqCC. Methods: Lipidomics, based on ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-...
Saved in:
Published in | Technology in cancer research & treatment Vol. 20; p. 15330338211049903 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Los Angeles, CA
SAGE Publications
2021
Sage Publications Ltd SAGE Publishing |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles of 40 patients with SqCC. Methods: Lipidomics, based on ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry, was applied to identify altered lipid metabolites between tumor and adjacent noninvolved tissues (ANIT), and partial least squares-discriminant analysis model facilitated the identification of differentially abundant lipids. The area under the receiver operator characteristic curve and variable importance in projection scores of the aforementioned model were calculated to select lipid profiles. Metabolic pathway analyses were completed using Kyoto Encyclopedia of Genes and Genomes and MetaboAnalyst. Results: Differences in lipid profiles were found between tumor and ANIT, early- and advanced-stage SqCC, and positive and negative lymph node metastases. The lipid profile panel was composed of five lipids—PC(44:4), diacylglycerol(36:5), sphingomyelin(d18:1/20:0), phosphatidylinositol(46:7), and HexCer-AP(t8:0/32:2 + O)—and could effectively differentiate between tumor and ANIT. Further, pathway analyses revealed alterations in several lipid metabolism pathways, including glycerophospholipid metabolism, glycosylphosphatidylinositol anchor biosynthesis, linoleic acid metabolism, glycerolipid metabolism, and sphingolipid metabolism. Conclusion: Our data revealed several changes in the tissue lipid profiles of patients with SqCC; moreover, we identified a lipid profile panel that could effectually distinguish tumor tissues from ANIT. We believe that our results provide new insights into the biological behavior of lung SqCC. |
---|---|
AbstractList | Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles of 40 patients with SqCC.
Lipidomics, based on ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry, was applied to identify altered lipid metabolites between tumor and adjacent noninvolved tissues (ANIT), and partial least squares-discriminant analysis model facilitated the identification of differentially abundant lipids. The area under the receiver operator characteristic curve and variable importance in projection scores of the aforementioned model were calculated to select lipid profiles. Metabolic pathway analyses were completed using Kyoto Encyclopedia of Genes and Genomes and MetaboAnalyst.
Differences in lipid profiles were found between tumor and ANIT, early- and advanced-stage SqCC, and positive and negative lymph node metastases. The lipid profile panel was composed of five lipids-PC(44:4), diacylglycerol(36:5), sphingomyelin(d18:1/20:0), phosphatidylinositol(46:7), and HexCer-AP(t8:0/32:2 + O)-and could effectively differentiate between tumor and ANIT. Further, pathway analyses revealed alterations in several lipid metabolism pathways, including glycerophospholipid metabolism, glycosylphosphatidylinositol anchor biosynthesis, linoleic acid metabolism, glycerolipid metabolism, and sphingolipid metabolism.
Our data revealed several changes in the tissue lipid profiles of patients with SqCC; moreover, we identified a lipid profile panel that could effectually distinguish tumor tissues from ANIT. We believe that our results provide new insights into the biological behavior of lung SqCC. Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles of 40 patients with SqCC. Methods: Lipidomics, based on ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry, was applied to identify altered lipid metabolites between tumor and adjacent noninvolved tissues (ANIT), and partial least squares-discriminant analysis model facilitated the identification of differentially abundant lipids. The area under the receiver operator characteristic curve and variable importance in projection scores of the aforementioned model were calculated to select lipid profiles. Metabolic pathway analyses were completed using Kyoto Encyclopedia of Genes and Genomes and MetaboAnalyst. Results: Differences in lipid profiles were found between tumor and ANIT, early- and advanced-stage SqCC, and positive and negative lymph node metastases. The lipid profile panel was composed of five lipids—PC(44:4), diacylglycerol(36:5), sphingomyelin(d18:1/20:0), phosphatidylinositol(46:7), and HexCer-AP(t8:0/32:2 + O)—and could effectively differentiate between tumor and ANIT. Further, pathway analyses revealed alterations in several lipid metabolism pathways, including glycerophospholipid metabolism, glycosylphosphatidylinositol anchor biosynthesis, linoleic acid metabolism, glycerolipid metabolism, and sphingolipid metabolism. Conclusion: Our data revealed several changes in the tissue lipid profiles of patients with SqCC; moreover, we identified a lipid profile panel that could effectually distinguish tumor tissues from ANIT. We believe that our results provide new insights into the biological behavior of lung SqCC. Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles of 40 patients with SqCC. Methods: Lipidomics, based on ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry, was applied to identify altered lipid metabolites between tumor and adjacent noninvolved tissues (ANIT), and partial least squares-discriminant analysis model facilitated the identification of differentially abundant lipids. The area under the receiver operator characteristic curve and variable importance in projection scores of the aforementioned model were calculated to select lipid profiles. Metabolic pathway analyses were completed using Kyoto Encyclopedia of Genes and Genomes and MetaboAnalyst. Results: Differences in lipid profiles were found between tumor and ANIT, early- and advanced-stage SqCC, and positive and negative lymph node metastases. The lipid profile panel was composed of five lipids—PC(44:4), diacylglycerol(36:5), sphingomyelin(d18:1/20:0), phosphatidylinositol(46:7), and HexCer-AP(t8:0/32:2 + O)—and could effectively differentiate between tumor and ANIT. Further, pathway analyses revealed alterations in several lipid metabolism pathways, including glycerophospholipid metabolism, glycosylphosphatidylinositol anchor biosynthesis, linoleic acid metabolism, glycerolipid metabolism, and sphingolipid metabolism. Conclusion: Our data revealed several changes in the tissue lipid profiles of patients with SqCC; moreover, we identified a lipid profile panel that could effectually distinguish tumor tissues from ANIT. We believe that our results provide new insights into the biological behavior of lung SqCC. |
Author | Hu, Sheng Zhang, Jianyong Zhang, Wenxiong Zhang, Lu Zeng, Weibiao Peng, Jinhua Yu, Dongliang Wei, Yiping Gong, Meng Xu, Jianjun Zheng, Wen |
AuthorAffiliation | 3 74720 The Affiliated Hospital of Guizhou Medical University , Guiyang, P. R. China 1 196534 The Second Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, P. R. China 2 Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network 34753 West China Hospital, Sichuan University , Chengdu, P. R. China |
AuthorAffiliation_xml | – name: 2 Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network 34753 West China Hospital, Sichuan University , Chengdu, P. R. China – name: 1 196534 The Second Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, P. R. China – name: 3 74720 The Affiliated Hospital of Guizhou Medical University , Guiyang, P. R. China |
Author_xml | – sequence: 1 givenname: Weibiao orcidid: 0000-0002-2564-879X surname: Zeng fullname: Zeng, Weibiao – sequence: 2 givenname: Wen surname: Zheng fullname: Zheng, Wen – sequence: 3 givenname: Sheng orcidid: 0000-0001-6046-3478 surname: Hu fullname: Hu, Sheng – sequence: 4 givenname: Jianyong orcidid: 0000-0003-0686-4427 surname: Zhang fullname: Zhang, Jianyong – sequence: 5 givenname: Wenxiong surname: Zhang fullname: Zhang, Wenxiong – sequence: 6 givenname: Jianjun surname: Xu fullname: Xu, Jianjun – sequence: 7 givenname: Dongliang surname: Yu fullname: Yu, Dongliang – sequence: 8 givenname: Jinhua surname: Peng fullname: Peng, Jinhua – sequence: 9 givenname: Lu surname: Zhang fullname: Zhang, Lu – sequence: 10 givenname: Meng surname: Gong fullname: Gong, Meng email: gongmeng@scu.edu.cn – sequence: 11 givenname: Yiping surname: Wei fullname: Wei, Yiping email: weiyip2000@hotmail.com |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34761720$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kktr3DAUhUVJaB7tD-imCLrpZhK9bW0Kw9BHYKCBpHQpZD0mGmzLkexA_33lOp02LVlJnHvOJ-nqnoGjPvYOgDcYXWBcVZeYU4oorQnGiEmJ6AtwOmurWTw67Jk4AWc57xEiQlD8EpxQVglcEXQK_HoY2mD0GGIPo4fbMAQbu2Ay9DHBdc4u59Dv4G3IeXJLHV6n6EPr8py4LlnXjxl-D-MdvLmfdBenDDeubeFGJxP62OlX4NjrNrvXj-s5-Pbp4-3my2r79fPVZr1dGU7JuGLC1JR7iVgtOLF1UyPMMbJN4w3i3rsiU-mlryS2qPZSGCJIxZtKWiYsoefgauHaqPdqSKHT6YeKOqhfQkw7pdMYTOsUs4aJBknSOMpsQyQxWhYyd1YTJmfWh4U1TE3nrCmPTLp9An1a6cOd2sUHVXNZfqcqgPePgBTvJ5dH1YVsSl9070qLFOFSMF5jyov13T_WfZxSX1qliMCUSC6YKC68uEyKOSfnD5fBSM0Tof6biJJ5-_crDonfI1AMF4sh6537c-zzxJ9gRr9s |
CitedBy_id | crossref_primary_10_1002_ctm2_1180 crossref_primary_10_1002_ijc_34423 |
Cites_doi | 10.1007/s00216-015-8484-x 10.1002/cncr.21690 10.1021/ac302154g 10.1016/j.bcp.2014.05.011 10.1038/342085a0 10.1186/1476-4598-9-186 10.1158/1055-9965.EPI-12-1424 10.1002/ijc.29517 10.1096/fasebj.9.7.7737456 10.1186/s13046-014-0109-2 10.1002/cem.1006 10.1165/rcmb.2010-0220RT 10.1002/ibd.21426 10.2174/1568009611313020008 10.1002/ijc.1449 10.1038/nmeth.3393 10.3322/caac.21590 10.1016/j.lungcan.2017.07.036 10.1016/j.aca.2019.02.010 10.1016/j.jpba.2020.113220 10.1161/01.ATV.15.10.1616 10.1016/j.copbio.2012.11.001 10.1242/jcs.115.5.983 10.1016/j.abb.2003.08.023 10.1002/ijc.28750 10.1158/0008-5472.CAN-13-2409 10.3389/fonc.2016.00205 10.1007/BF02815356 10.1038/s41598-018-25552-z 10.1016/j.jtho.2016.05.024 10.1016/j.chest.2016.10.010 10.1111/j.1742-4658.2012.08644.x 10.1111/jcmm.13782 10.1002/ijc.29210 10.1016/j.freeradbiomed.2013.01.029 10.1097/JTO.0b013e318189f551 10.1016/j.jpba.2014.07.038 10.1053/j.seminoncol.2014.02.005 |
ContentType | Journal Article |
Copyright | The Author(s) 2021 The Author(s) 2021. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2021 2021 SAGE Publications |
Copyright_xml | – notice: The Author(s) 2021 – notice: The Author(s) 2021. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2021 2021 SAGE Publications |
DBID | AFRWT CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7TO 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH H94 K9. M0S PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
DOI | 10.1177/15330338211049903 |
DatabaseName | Sage Journals GOLD Open Access 2024 Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database Oncogenes and Growth Factors Abstracts ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE Publicly Available Content Database CrossRef |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: AFRWT name: Sage Journals GOLD Open Access 2024 url: http://journals.sagepub.com/ sourceTypes: Publisher – sequence: 5 dbid: 7X7 name: Health & Medical Collection url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1533-0338 |
EndPage | 15330338211049903 |
ExternalDocumentID | oai_doaj_org_article_4dc46b092be34db292ca99f75eda2492 10_1177_15330338211049903 34761720 10.1177_15330338211049903 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: the Funding Scheme for Outstanding Young talents in Jiangxi Province grantid: 20162BCB23058 – fundername: the Innovation Fund of Nanchang University grantid: cx2016396 – fundername: the National Natural Science Foundation of China grantid: No. 81560345; No. 81860379 – fundername: ; grantid: No. 81560345; No. 81860379 – fundername: ; grantid: 20162BCB23058 – fundername: ; grantid: cx2016396 |
GroupedDBID | --- -TM 0R~ 123 53G 54M 7X7 8FI 8FJ AABMB AADCB AADUE AAJPV AAJQC AARDL AARIX AATBZ ABAWP ABEIX ABFWQ ABKRH ABQXT ABRHV ABUWG ABVFX ACARO ACDSZ ACDXX ACGFS ACGZU ACOFE ACROE ACSIQ ACUIR ADBBV ADOGD ADPDF ADZZY AENEX AEQLS AERKM AEUHG AEUIJ AEWDL AEWHI AEXNY AFCOW AFEET AFKRA AFKRG AFRWT AFUIA AGNHF AJUZI ALIPV ALJHS ALMA_UNASSIGNED_HOLDINGS AOIJS ARTOV AUTPY AYAKG B8M BDDNI BENPR BKSCU BPHCQ BSEHC BVXVI CCPQU CDWPY CFDXU DC- DC. DOPDO DV7 EBS EJD EMOBN F5P FYUFA GROUPED_DOAJ GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION HMCUK HYE J8X JCYGO K.F M4V O9- OK1 OVD OVEED P2P PIMPY PQQKQ ROL RPM SFC SJN TEORI UDS UKHRP Y4B ZONMY ZPPRI ZRKOI ZSSAH CGR CUY CVF ECM EIF H13 NPM AAYXX CITATION 3V. 7TO 7XB 8FK AZQEC DWQXO H94 K9. PQEST PQUKI PRINS 7X8 5PM |
ID | FETCH-LOGICAL-c532t-46c835f9048652d8b801510dbbfc05ffe86539f9f791d08f96c26275b79d46d23 |
IEDL.DBID | RPM |
ISSN | 1533-0346 |
IngestDate | Tue Oct 22 15:00:29 EDT 2024 Tue Sep 17 21:15:12 EDT 2024 Sat Aug 17 03:06:46 EDT 2024 Thu Oct 10 22:17:32 EDT 2024 Wed Oct 09 16:52:18 EDT 2024 Sat Sep 28 08:20:40 EDT 2024 Tue Jul 16 20:50:27 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | mass spectrometry non-small-cell lung carcinoma lipidomics lipid metabolism squamous cell carcinoma |
Language | English |
License | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c532t-46c835f9048652d8b801510dbbfc05ffe86539f9f791d08f96c26275b79d46d23 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0001-6046-3478 0000-0002-2564-879X 0000-0003-0686-4427 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591777/ |
PMID | 34761720 |
PQID | 2613295646 |
PQPubID | 4450582 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_4dc46b092be34db292ca99f75eda2492 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8591777 proquest_miscellaneous_2596458135 proquest_journals_2613295646 crossref_primary_10_1177_15330338211049903 pubmed_primary_34761720 sage_journals_10_1177_15330338211049903 |
PublicationCentury | 2000 |
PublicationDate | 2021-00-00 |
PublicationDateYYYYMMDD | 2021-01-01 |
PublicationDate_xml | – year: 2021 text: 2021-00-00 |
PublicationDecade | 2020 |
PublicationPlace | Los Angeles, CA |
PublicationPlace_xml | – name: Los Angeles, CA – name: United States – name: Thousand Oaks – name: Sage CA: Los Angeles, CA |
PublicationTitle | Technology in cancer research & treatment |
PublicationTitleAlternate | Technol Cancer Res Treat |
PublicationYear | 2021 |
Publisher | SAGE Publications Sage Publications Ltd SAGE Publishing |
Publisher_xml | – name: SAGE Publications – name: Sage Publications Ltd – name: SAGE Publishing |
References | Ros-Mazurczyk, Jelonek, Marczyk 2017; 112 Lin, Helsby, Rowan, Ferguson 2011; 17 Socinski, Obasaju, Gandara 2016; 11 Wang, Shen, Shi 2014; 33 Lemonnier, Dillehay, Vespremi, Abrams, Brody, Schmelz 2003; 419 Hiller, Metallo 2013; 24 2020; 41 Suarna, Dean, May, Stocker 1995; 15 Miyoshi, Iwasaki, Tomono, Higashi, Ohshima 2013; 60 Chen, Ma, Shen 2018; 2018 Yu, Chen, Zhu 2018; 16 Grunt, Mariani 2013; 13 Lv, Gao, Zhang, Wu, Shen, Wang 2018; 22 Tsugawa, Cajka, Kind 2015; 12 Noreldeen, Du, Li, Liu, Wang, Xu 2020; 185 Bylesjö, Rantalainen, Cloarec, Nicholson, Holmes, Trygg 2006; 20 Kolesnick 1994; 21 Siegel, Miller, Jemal 2020; 70 Jensen, Fusch, Jaeger, Peheim, Horber 1995; 80 Deng, Zhang, Tan 2019; 1061 Wolf, Sadetzki, Kanety 2006; 106 Liu, Patwardhan, Xie, Gu, Giuliano, Cabot 2011; 39 Ferlay, Soerjomataram, Dikshit 2015; 136 Trousil, Lee, Pinato 2014; 74 Tan, Camilleri-Broët, Tan 2014; 135 Goldkorn, Filosto 2010; 43 Alberg, Armeson, Pierce 2013; 22 Hirsch, Spreafico, Novello, Wood, Simms, Papotti 2008; 3 Chen, Ma, Zhong 2018; 8 Robinson, Millrain, Antoniou, Simpson, Mellor 1989; 342 Liu, Chen, Momin 2010; 9 Santos, Schulze 2012; 279 Yang, Cui, Zhang 2015; 407 Visca, Sebastiani, Botti 2004; 24 Al-Zoughbi, Huang, Paramasivan 2014; 41 Fhaner, Liu, Ji, Simpson, Reid 2012; 84 Iorio, Caramujo, Cecchetti 2016; 6 Deacon, Pettitt, Webb 2002; 115 Marien, Meister, Muley 2015; 137 Morjani, Aouali, Belhoussine, Veldman, Levade, Manfait 2001; 94 Kisluk, Ciborowski, Niemira, Kretowski, Niklinski 2014; 101 Detterbeck, Boffa, Kim, Tanoue 2017; 151 Nishizuka 1995; 9 Fumarola, Bonelli, Petronini, Alfieri 2014; 90 bibr2-15330338211049903 bibr28-15330338211049903 bibr18-15330338211049903 bibr5-15330338211049903 bibr15-15330338211049903 bibr12-15330338211049903 Chen Y (bibr20-15330338211049903) 2018; 2018 bibr7-15330338211049903 bibr13-15330338211049903 bibr26-15330338211049903 bibr16-15330338211049903 bibr36-15330338211049903 bibr39-15330338211049903 bibr29-15330338211049903 bibr19-15330338211049903 bibr3-15330338211049903 Jensen EX (bibr33-15330338211049903) 1995; 80 bibr43-15330338211049903 bibr6-15330338211049903 bibr30-15330338211049903 bibr10-15330338211049903 bibr40-15330338211049903 bibr11-15330338211049903 Visca P (bibr35-15330338211049903) 2004; 24 bibr9-15330338211049903 bibr27-15330338211049903 bibr1-15330338211049903 Yu Z (bibr21-15330338211049903) 2018; 16 bibr24-15330338211049903 bibr4-15330338211049903 bibr31-15330338211049903 bibr37-15330338211049903 bibr14-15330338211049903 bibr17-15330338211049903 bibr41-15330338211049903 bibr44-15330338211049903 bibr34-15330338211049903 bibr42-15330338211049903 bibr32-15330338211049903 bibr22-15330338211049903 bibr8-15330338211049903 Yan Z (bibr23-15330338211049903) 2020; 41 bibr25-15330338211049903 bibr38-15330338211049903 Liu YY (bibr45-15330338211049903) 2011; 39 |
References_xml | – volume: 151 start-page: 193 issue: 1 year: 2017 end-page: 203 article-title: The eighth edition lung cancer stage classification publication-title: Chest contributor: fullname: Tanoue – volume: 185 start-page: 113220 year: 2020 article-title: Serum lipidomic biomarkers for non-small cell lung cancer in nonsmoking female patients publication-title: J Pharm Biomed Anal contributor: fullname: Xu – volume: 15 start-page: 1616 issue: 10 year: 1995 end-page: 1624 article-title: Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha-tocopherol and ascorbate publication-title: Arterioscler, Thromb, Vasc Biol contributor: fullname: Stocker – volume: 9 start-page: 484 issue: 7 year: 1995 end-page: 496 article-title: Protein kinase C and lipid signaling for sustained cellular responses publication-title: FASEB J contributor: fullname: Nishizuka – volume: 43 start-page: 259 issue: 3 year: 2010 end-page: 268 article-title: Lung injury and cancer: mechanistic insights into ceramide and EGFR signaling under cigarette smoke publication-title: Am J Respir Cell Mol Biol contributor: fullname: Filosto – volume: 3 start-page: 1468 issue: 12 year: 2008 end-page: 1481 article-title: The prognostic and predictive role of histology in advanced non-small cell lung cancer: a literature review publication-title: J Thorac Oncol contributor: fullname: Papotti – volume: 21 start-page: 287 issue: 2–3 year: 1994 end-page: 297 article-title: Signal transduction through the sphingomyelin pathway publication-title: Mol Chem Neuropathol contributor: fullname: Kolesnick – volume: 17 start-page: 1021 issue: 4 year: 2011 end-page: 1029 article-title: Using metabolomic analysis to understand inflammatory bowel diseases publication-title: Inflamm Bowel Dis contributor: fullname: Ferguson – volume: 22 start-page: 5155 issue: 10 year: 2018 end-page: 5159 article-title: Heterogeneity of lipidomic profiles among lung cancer subtypes of patients publication-title: J Cell Mol Med contributor: fullname: Wang – volume: 137 start-page: 1539 issue: 7 year: 2015 end-page: 1548 article-title: Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles publication-title: Int J Cancer contributor: fullname: Muley – volume: 60 start-page: 73 year: 2013 end-page: 79 article-title: Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein publication-title: Free Radical Biol Med contributor: fullname: Ohshima – volume: 24 start-page: 4169 issue: 6 year: 2004 end-page: 4173 article-title: Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma publication-title: Anticancer Res contributor: fullname: Botti – volume: 8 start-page: 7137 issue: 1 year: 2018 article-title: Simultaneous quantification of serum monounsaturated and polyunsaturated phosphatidylcholines as potential biomarkers for diagnosing non-small cell lung cancer publication-title: Sci Rep contributor: fullname: Zhong – volume: 419 start-page: 129 issue: 2 year: 2003 end-page: 138 article-title: Sphingomyelin in the suppression of colon tumors: prevention versus intervention publication-title: Arch Biochem Biophys contributor: fullname: Schmelz – volume: 24 start-page: 60 issue: 1 year: 2013 end-page: 68 article-title: Profiling metabolic networks to study cancer metabolism publication-title: Curr Opin Biotechnol contributor: fullname: Metallo – volume: 112 start-page: 69 year: 2017 end-page: 74 article-title: Serum lipid profile discriminates patients with early lung cancer from healthy controls publication-title: Lung Cancer contributor: fullname: Marczyk – volume: 101 start-page: 40 year: 2014 end-page: 49 article-title: Proteomics biomarkers for non-small cell lung cancer publication-title: J Pharm Biomed Anal contributor: fullname: Niklinski – volume: 22 start-page: 1374 issue: 8 year: 2013 end-page: 1382 article-title: Plasma sphingolipids and lung cancer: a population-based, nested case-control study publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Pierce – volume: 20 start-page: 341 issue: 8–10 year: 2006 end-page: 351 article-title: OPLS Discriminant analysis: combining the strengths of PLS-DA and SIMCA classification contributor: fullname: Trygg – volume: 39 start-page: 425 issue: 2 year: 2011 end-page: 431 article-title: Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma publication-title: Int J Oncol contributor: fullname: Cabot – volume: 106 start-page: 966 issue: 4 year: 2006 end-page: 973 article-title: Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients publication-title: Cancer contributor: fullname: Kanety – volume: 41 start-page: 281 issue: 2 year: 2014 end-page: 295 article-title: Tumor macroenvironment and metabolism publication-title: Semin Oncol contributor: fullname: Paramasivan – volume: 16 start-page: 761 issue: 1 year: 2018 end-page: 768 article-title: Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: a pilot study publication-title: Oncol Lett contributor: fullname: Zhu – volume: 74 start-page: 6867 issue: 23 year: 2014 end-page: 6877 article-title: Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway publication-title: Cancer Res contributor: fullname: Pinato – volume: 407 start-page: 5065 issue: 17 year: 2015 end-page: 5077 article-title: Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers publication-title: Anal Bioanal Chem contributor: fullname: Zhang – volume: 94 start-page: 157 issue: 2 year: 2001 end-page: 165 article-title: Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets publication-title: Int J Cancer contributor: fullname: Manfait – volume: 80 start-page: 2181 issue: 7 year: 1995 end-page: 2185 article-title: Impact of chronic cigarette smoking on body composition and fuel metabolism publication-title: J Clin Endocrinol Metab contributor: fullname: Horber – volume: 1061 start-page: 60 year: 2019 end-page: 69 article-title: WaveICA: a novel algorithm to remove batch effects for large-scale untargeted metabolomics data based on wavelet analysis publication-title: Anal Chim Acta contributor: fullname: Tan – volume: 9 start-page: 186 year: 2010 article-title: Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry publication-title: Mol Cancer contributor: fullname: Momin – volume: 136 start-page: E359 issue: 5 year: 2015 end-page: E386 article-title: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 publication-title: Int J Cancer contributor: fullname: Dikshit – volume: 135 start-page: 1092 issue: 5 year: 2014 end-page: 1100 article-title: Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics publication-title: Int J Cancer contributor: fullname: Tan – volume: 279 start-page: 2610 issue: 15 year: 2012 end-page: 2623 article-title: Lipid metabolism in cancer publication-title: FEBS J contributor: fullname: Schulze – volume: 90 start-page: 197 issue: 3 year: 2014 end-page: 207 article-title: Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer publication-title: Biochem Pharmacol contributor: fullname: Alfieri – volume: 2018 start-page: 5276240 year: 2018 article-title: Serum lipidomics profiling to identify biomarkers for non-small cell lung cancer publication-title: BioMed Res Int contributor: fullname: Shen – volume: 41 start-page: 145 issue: 2 year: 2020 end-page: 151 article-title: The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China publication-title: Zhonghua Liu Xing Bing Xue Za Zhi – volume: 11 start-page: 1411 issue: 9 year: 2016 end-page: 1422 article-title: Clinicopathologic features of advanced squamous NSCLC publication-title: J Thorac Oncol contributor: fullname: Gandara – volume: 6 start-page: 205 year: 2016 article-title: Key players in choline metabolic reprograming in triple-negative breast cancer publication-title: Front Oncol contributor: fullname: Cecchetti – volume: 342 start-page: 85 issue: 6245 year: 1989 end-page: 87 article-title: A glycophospholipid anchor is required for Qa-2-mediated T cell activation publication-title: Nature contributor: fullname: Mellor – volume: 115 start-page: 983 issue: Pt 5 year: 2002 end-page: 989 article-title: Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2–arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M publication-title: J Cell Sci contributor: fullname: Webb – volume: 84 start-page: 8917 issue: 21 year: 2012 end-page: 8926 article-title: Comprehensive lipidome profiling of isogenic primary and metastatic colon adenocarcinoma cell lines publication-title: Anal Chem contributor: fullname: Reid – volume: 12 start-page: 523 issue: 6 year: 2015 end-page: 526 article-title: MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis publication-title: Nat Methods contributor: fullname: Kind – volume: 13 start-page: 188 issue: 2 year: 2013 end-page: 204 article-title: Novel approaches for molecular targeted therapy of breast cancer: interfering with PI3K/AKT/mTOR signaling publication-title: Curr Cancer Drug Targets contributor: fullname: Mariani – volume: 33 start-page: 109 issue: 1 year: 2014 article-title: Detection of ALK protein expression in lung squamous cell carcinomas by immunohistochemistry publication-title: J Exp Clin Cancer Res contributor: fullname: Shi – volume: 70 start-page: 7 issue: 1 year: 2020 end-page: 30 article-title: Cancer statistics, 2020 publication-title: CA Cancer J Clin contributor: fullname: Jemal – ident: bibr12-15330338211049903 doi: 10.1007/s00216-015-8484-x – ident: bibr34-15330338211049903 doi: 10.1002/cncr.21690 – ident: bibr13-15330338211049903 doi: 10.1021/ac302154g – ident: bibr31-15330338211049903 doi: 10.1016/j.bcp.2014.05.011 – ident: bibr32-15330338211049903 doi: 10.1038/342085a0 – ident: bibr43-15330338211049903 doi: 10.1186/1476-4598-9-186 – ident: bibr42-15330338211049903 doi: 10.1158/1055-9965.EPI-12-1424 – ident: bibr28-15330338211049903 doi: 10.1002/ijc.29517 – ident: bibr36-15330338211049903 doi: 10.1096/fasebj.9.7.7737456 – ident: bibr5-15330338211049903 doi: 10.1186/s13046-014-0109-2 – ident: bibr15-15330338211049903 doi: 10.1002/cem.1006 – ident: bibr41-15330338211049903 doi: 10.1165/rcmb.2010-0220RT – ident: bibr14-15330338211049903 doi: 10.1002/ibd.21426 – ident: bibr30-15330338211049903 doi: 10.2174/1568009611313020008 – ident: bibr44-15330338211049903 doi: 10.1002/ijc.1449 – ident: bibr17-15330338211049903 doi: 10.1038/nmeth.3393 – volume: 24 start-page: 4169 issue: 6 year: 2004 ident: bibr35-15330338211049903 publication-title: Anticancer Res contributor: fullname: Visca P – ident: bibr1-15330338211049903 doi: 10.3322/caac.21590 – ident: bibr27-15330338211049903 doi: 10.1016/j.lungcan.2017.07.036 – ident: bibr18-15330338211049903 doi: 10.1016/j.aca.2019.02.010 – ident: bibr19-15330338211049903 doi: 10.1016/j.jpba.2020.113220 – ident: bibr10-15330338211049903 doi: 10.1161/01.ATV.15.10.1616 – ident: bibr24-15330338211049903 doi: 10.1016/j.copbio.2012.11.001 – ident: bibr37-15330338211049903 doi: 10.1242/jcs.115.5.983 – ident: bibr39-15330338211049903 doi: 10.1016/j.abb.2003.08.023 – ident: bibr22-15330338211049903 doi: 10.1002/ijc.29517 – ident: bibr9-15330338211049903 doi: 10.1002/ijc.28750 – ident: bibr26-15330338211049903 doi: 10.1158/0008-5472.CAN-13-2409 – ident: bibr25-15330338211049903 doi: 10.3389/fonc.2016.00205 – ident: bibr40-15330338211049903 doi: 10.1007/BF02815356 – ident: bibr38-15330338211049903 doi: 10.1038/s41598-018-25552-z – ident: bibr3-15330338211049903 doi: 10.1016/j.jtho.2016.05.024 – ident: bibr16-15330338211049903 doi: 10.1016/j.chest.2016.10.010 – volume: 41 start-page: 145 issue: 2 year: 2020 ident: bibr23-15330338211049903 publication-title: Zhonghua Liu Xing Bing Xue Za Zhi contributor: fullname: Yan Z – volume: 80 start-page: 2181 issue: 7 year: 1995 ident: bibr33-15330338211049903 publication-title: J Clin Endocrinol Metab contributor: fullname: Jensen EX – volume: 2018 start-page: 5276240 year: 2018 ident: bibr20-15330338211049903 publication-title: BioMed Res Int contributor: fullname: Chen Y – ident: bibr7-15330338211049903 doi: 10.1111/j.1742-4658.2012.08644.x – ident: bibr29-15330338211049903 doi: 10.1111/jcmm.13782 – volume: 16 start-page: 761 issue: 1 year: 2018 ident: bibr21-15330338211049903 publication-title: Oncol Lett contributor: fullname: Yu Z – volume: 39 start-page: 425 issue: 2 year: 2011 ident: bibr45-15330338211049903 publication-title: Int J Oncol contributor: fullname: Liu YY – ident: bibr2-15330338211049903 doi: 10.1002/ijc.29210 – ident: bibr11-15330338211049903 doi: 10.1016/j.freeradbiomed.2013.01.029 – ident: bibr4-15330338211049903 doi: 10.1097/JTO.0b013e318189f551 – ident: bibr8-15330338211049903 doi: 10.1016/j.jpba.2014.07.038 – ident: bibr6-15330338211049903 doi: 10.1053/j.seminoncol.2014.02.005 |
SSID | ssj0026631 |
Score | 2.324198 |
Snippet | Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue... Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles... Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue... |
SourceID | doaj pubmedcentral proquest crossref pubmed sage |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 15330338211049903 |
SubjectTerms | Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Diglycerides Discriminant analysis Genomes Glycosylphosphatidylinositol Humans Linoleic acid Lipid metabolism Lipidomics - methods Lipids Lipids - analysis Liquid chromatography Lung cancer Lymph nodes Lymphatic Metastasis - pathology Male Mass Spectrometry - methods Mass spectroscopy Metabolic Networks and Pathways Metabolic pathways Metabolism Metabolites Metastases Middle Aged Original Phosphatidylinositol ROC Curve Sphingomyelin Squamous cell carcinoma Tumors |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fS9xAEB6KD9IXsbXWWCsrFApCaLK_kn3UQxFBEaroW8hmd1HQXOud_78z2b3TQ8UXX7MJTObL7H6T2f0G4Jfi0hppdG4LHXLpa5sbnAhzW_u61DgYWjrgfHKqjy7k8ZW6etbqi_aERXng6Lg_0nVS28Jw64V0lhvetcaESnnXktrdMPuWapZMpVQL19Ey1TBJXolITYHJGGU7SPFnHbLSKjSI9b_GMF9ulHy222tYgA5XYSUxR7YXLf4Cn3z_FZZPUm18DcLeUy2ajQOjrtSOzhxPGBJTFqu7uFCx88HXcZydxZ7dE3riLGqsTtjlzfSa_f3_0NJ_ATbyt7dsRD2H-vFd-w0uDg_OR0d56qKQd0rwaS51hywrGNLWU9zVFqHAQHTWhq5QIfia1GkDutSUrqiD0R0n6WJbGSe142Idlvpx7zeAtZ2Wlde-sIiiFq0VFkGwyGhcEWpRZLA782rzL4plNGXSE38BQQb75Pf5jaRzPVxA9JuEfvMe-hlszVBrUvBNGkwKBce8T-oMdubDGDZUC2l7j65rMOvTUtWlUBl8jyDPLRGyIl6Hr1MtwL9g6uJIf3M9SHOTGmBVVRn8pg_lyaQ3vbD5EV74AZ85bbUZ_gxtwdL0_sH_RK40tdtDWDwCP2IN8g priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3_a9UwED90A_EX8bvVKREEQQimSZo2P8n22BjCxkM33G-laRI3mO22vv3_3rV57_mY-mvT0stdLvnkLvkcwIdCame1NdwJE7kOleMWJ0LuqlDlBhtjQxecj47N4an-elacpYDbkI5VLufEcaL2fUsx8s-I9JVEMK_Nl6trTlWjKLuaSmjch22Za0rTbu_tH8-_rbZcuJ4mxlTFhdIm5TWJcomeCdyg0Q4IYf-yalZamUYC_7-hzruHJ_84ATYuSgeP4VFCk2x3Mv8TuBe6p_DgKOXLn0HcXeenWR8ZVar2dA95YAhW2ZTxxcWLnYz6n9rZfKrjPdAX84l3dWA_Lhbn7Pv1bUOxAjYLl5dsRnWIuv5X8xxOD_ZPZoc8VVbgbaHkgmvTIvKKlvj2Cukrh-ZB5_TOxVYUMYaKGGujjaXNvaiiNa0kOmNXWq-Nl-oFbHV9F14Ba1qjy2CCcGhZoxqnnG-kQ5TjRayUyODTUqv11USgUeeJY_yOCTLYI72vXiTu6_FBf_OzTq5Ua99q44SVLijtnbSybSyKWgT8sbYyg52l1erkkEO9Hj4ZvF81oytRfqTpAqquxp2g0UWVqyKDl5ORV5IoXRLWw-6UG-bfEHWzpbs4H-m6iSGwLMsMPtJAWYv0Ty28_n8H3sBDSQdrxjjQDmwtbm7DW0RGC_cuDf_fo78ILQ priority: 102 providerName: ProQuest – databaseName: Sage Journals GOLD Open Access 2024 dbid: AFRWT link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fa9swED66FMZexn7PXTc0GAwGXhVJlq2nkYWFMugoW0r7ZixLWguNvTbJw_773dlyutAO9mrZ-Hyns77Tnb4DeJcJZY0yOrVch1T5wqYGf4SpLXwx1jgYKjrgfPRNH56or2fZ2Q60w1mYqMHlRyqrQom6nzV5N-1GH8Qk4wGBFI7BFUUvCNm5_LReLcp-u3voqkFXKD-9XlBqu6aCyN_pcLztHuwKYsUdwe5k9v10vonRcAGOFKsy5VLpmAi986VbS1nH-H8XTL1dbflXyVi3is0ewcMIP9mkny-PYcc3T-D-UUywP4UwuUloszYwam3t6ODykiG6ZX2KGFc7Nu8M1o-z477x95KeOO6JWpfs9GJ1zn5crSvaXGBTf3nJptS4qGkX1TM4mX2ZTw_T2IohrTMpVqnSNUK1YIigLxOusGhP9GZnbah5FoIviOI2mJCbseNFMLoWxH9sc-OUdkI-h1HTNv4lsKrWKvfac4tTQcvKSusqYREWOR4KyRP4MGi1_NUzbpTjSEp-ywQJfCa9b24ksuzuQnv9s4y-VypXK225EdZL5awwoq4Mipp5fLEyIoH9wWrlMP9KjCylwOBR6QTebobR9yihUjUeVVdi6KhVVoxllsCL3sgbSaTKCRzi5-Rb5t8SdXukuTjv-L2JUjDP8wTe00S5EemfWtj77ztfwQNBRTndHtI-jFbXa_8aUdXKvome8Adv9BpT priority: 102 providerName: SAGE Publications |
Title | Application of Lipidomics for Assessing Tissue Lipid Profiles of Patients With Squamous Cell Carcinoma |
URI | https://journals.sagepub.com/doi/full/10.1177/15330338211049903 https://www.ncbi.nlm.nih.gov/pubmed/34761720 https://www.proquest.com/docview/2613295646 https://search.proquest.com/docview/2596458135 https://pubmed.ncbi.nlm.nih.gov/PMC8591777 https://doaj.org/article/4dc46b092be34db292ca99f75eda2492 |
Volume | 20 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_aDsZexr7nrQsaDAYDN4oky9ZjGhrKICV0Kc2bsSxpDSRO16T__06ynC50e9mTQbLRcafz3elOvwP4kjGhlVAy1VS6VNhCpwp_hKkubDGQOOkqf8F5ciHPr8T3eTY_gKy7CxOK9mu9OGmWq5NmcRNqK29Xdb-rE-tPJyOPuZbnef8QDnPOuxA9RlloQiNIKk8pFzKmMj3Kkh-jGJP5oAc9feqb6HCReyNO9-xSgO__m8_5uHTyj_qvYJLGL-B59CXJsKX5JRzY5hU8ncRs-Wtww4fsNFk74vtUG38LeUPQVSVtvhdNF5kF7rfzZNp28d74L6Yt6uqGXC-2N-THr_vKnxSQkV0uych3IWrWq-oNXI3PZqPzNPZVSOuMs20qZI1-l1MebS9jptAoHFRNo7WraeacLTxerVMuVwNDC6dkzTyYsc6VEdIw_haOmnVj3wOpailyKy3VKFfJK821qZhGH8dQV3CawLeOq-VtC59RDiLC-CNpJHDq-b570SNfh4H13c8yyr8UphZSU8W05cJoplhdKSQ1s7iwUCyB405qZVTHTYlhImcYCQqZwOfdNCqSz45UjUXWlRgHSpEVA54l8K4V8o6SbpMkkO-Jf4_U_RncuwGsO-7VBL76jfJA0j-58OG_1_gIz5ivuAkHRMdwtL27t5_QZdrqHirKPO_Bk-H48nqGz9Ozi-llLxxA9IL6_AbJxxTx |
link.rule.ids | 230,315,733,786,790,870,891,2115,4043,12083,21416,21994,27884,27954,27955,27956,31752,31753,33777,33778,43343,43838,44978,45366,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED7BkIAXNH4HNjASEhJSRGo7dvyEtoqpwDpNohN9i-LYZpNGsi3d_89d4rarBrzmEuV857M_--zvAN7nXFojjUptpkIqfWFTgwNhagtfjBQKQ0UXnKdHanIiv83zedxw6-KxyuWY2A_Urq1pj_wTIn3BEcxL9fniMqWqUZRdjSU07sI9KYSkfq7n6wUXzqaRL1WkmZAqZjWJcImeZbg8o_UPgv5lzaw4L_X0_X_DnLePTt44_9VPSQfb8ChiSbY3OP8x3PHNE7g_jdnypxD21tlp1gZGdaod3ULuGEJVNuR7cepis976g5wdD1W8O_rieGBd7djPs8Up-3F5XdFOARv783M2pipETfu7egYnB19m40ka6yqkdS74IpWqRtwVDLHt5dwVFp2DoemsDXWWh-AL4qsNJmgzclkRjKo5kRlbbZxUjovnsNW0jX8JrKqV1F75zKJflaissK7iFjGOy0IhsgQ-Lq1aXgz0GeUoMozfckEC-2T31YvEfN0_aK9-lTGQSulqqWxmuPVCOssNryuDquYefywNT2Bn6bUyhmNXrjtPAu9WYgwkyo5UjUfTlbgOVDIvRiJP4MXg5JUmQmpCetgcveH-DVU3Jc3ZaU_WTfyAWusEPlBHWav0Tyu8-n8D3sKDyWx6WB5-Pfr-Gh5yOmLT7wjtwNbi6trvIkZa2Dd9IPwBrwUJtA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED_BkCZe-GYEBhgJCQkprWs7Tvw4CtX46FSJTUy8RHFss4o2LWv6wl_POXG6lcHLXm1H_ri73J3v_DuA1wkTWgklY02li4XNdKzwRxjrzGYDiZ2u8A-cx0fy8ER8Ok1OL5X6apL2Sz3tVbN5r5qeNbmVy3nZ7_LE-pPx0GOupWnaXxrXvwm3UGZZ2jnqwddCRRqgUnlMuZAhoOmxlnwbRc_Muz5o71NfSoeL1KtyuqWdGhD_f1meVxMoL2WBNYppdBe-d1tq81F-9ta17pW__0J7vNae78GdYK6Sg3bIfbhhqwewOw4B-YfgDi4C4GThiC-FbfxD5xVBa5i0IWXUjuS4IXDbTyZtofCV_2LSAruuyLdpfUa-_loX_jKCDO1sRoa-0FG1mBeP4GT04Xh4GIfSDXGZcFbHQpZo2jnlAf0SZjKN9EfpN1q7kibO2cxD4jrlUjUwNHNKlszjJetUGSEN449hp1pU9gmQopQitdJSjawjeaG5NgXTaEYZ6jJOI3jbkSxftggd-SCAmF8hdQTvPFE3Az24dtOwOP-Rh-POhSmF1FQxbbkwmilWFgqXmlicWCgWwX7HEnmQ-FWOnihn6GwKGcGrTTfKqg_AFJXFo8vR1ZQiyQY8iWCv5aDNSjoOjCDd4q2tpW73IKs0eOCBNSJ447nwYkn_PYWn157jJexO3o_yLx-PPj-D28zn9zTXUfuwU5-v7XM00Gr9ohHFP7b9NFY |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Application+of+Lipidomics+for+Assessing+Tissue+Lipid+Profiles+of+Patients+With+Squamous+Cell+Carcinoma&rft.jtitle=Technology+in+cancer+research+%26+treatment&rft.au=Zeng%2C+Weibiao&rft.au=Zheng%2C+Wen&rft.au=Hu%2C+Sheng&rft.au=Zhang%2C+Jianyong&rft.date=2021&rft.pub=Sage+Publications+Ltd&rft.issn=1533-0346&rft.eissn=1533-0338&rft.volume=20&rft_id=info:doi/10.1177%2F15330338211049903 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1533-0346&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1533-0346&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1533-0346&client=summon |