Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition - Hauke, Jan; Riessland, Markus; Lunke, Sebastian; Eyüpoglu, Ilker Y.; Blümcke, Ingmar; El-Osta, Assam; Wirth, Brunhilde; Hahnen, Eric (Human molecular genetics, 2009)
Keywords: Biological and medical sciences; Cell Line; CpG Islands; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Depsipeptides - pharmacology; DNA Methylation; Enzyme Inhibitors - pharmacology; Fibroblasts - drug effects; Fibroblasts - metabolism; Fundamental and applied biological sciences. Psychology; Gene Silencing; Genetics of eukaryotes. Biological and molecular evolution; Hippocampus - drug effects; Hippocampus - metabolism; Histone Deacetylase Inhibitors; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Humans; Hydroxamic Acids - pharmacology; In Vitro Techniques; Medical sciences; Methyl-CpG-Binding Protein 2 - genetics; Methyl-CpG-Binding Protein 2 - metabolism; Molecular and cellular biology; Muscular Atrophy, Spinal - drug therapy; Muscular Atrophy, Spinal - genetics; Muscular Atrophy, Spinal - metabolism; Neurology; Promoter Regions, Genetic; Severity of Illness Index; SMN Complex Proteins - genetics; SMN Complex Proteins - metabolism; Survival of Motor Neuron 2 Protein; Histone deacetylase; Nervous system diseases; Neuromuscular diseases; Spinal amyotrophy; Motor neuron; Survival; Gene silencing; DNA; Central nervous system disease; Genetics; Degenerative disease; Inhibition; Methylation; Spinal cord disease