Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial

• Published in: Critical care (London, England) Vol. 23; no. 1; pp. 69 - 11
• Main Authors: Peters, Mark J., Woolfall, Kerry, Khan, Imran, Deja, Elisabeth, Mouncey, Paul R., Wulff, Jerome, Mason, Alexina, Agbeko, Rachel S., Draper, Elizabeth S., Fenn, Blaise, Gould, Doug W., Koelewyn, Abby, Klein, Nigel, Mackerness, Christine, Martin, Sian, O’Neill, Lauran, Ray, Samiran, Ramnarayan, Padmanabhan, Tibby, Shane, Thorburn, Kentigern, Tume, Lyvonne, Watkins, Jason, Wellman, Paul, Harrison, David A., Rowan, Kathryn M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.03.2019; BioMed Central; BMC
• Subjects: Antipyretics; Care and treatment; Child; Child, Preschool; Childhood fever; Children; Clinical trials; Critical Illness - therapy; Female; Fever; Fever - etiology; Fever - physiopathology; Focus Groups - methods; Humans; Infant; Infection; Infections - complications; Infections - physiopathology; Intensive Care Units, Pediatric - organization & administration; Intensive Care Units, Pediatric - statistics & numerical data; Male; Mortality; Paediatric intensive care; Paracetamol; Patient outcomes; Pediatric intensive care; Pediatrics; Pilot Projects; Sepsis; Surveys and Questionnaires; Threshold Limit Values; Treatment Outcome; United Kingdom; United Kingdom; Infection; Paracetamol; Clinical trial; Sepsis; Paediatric intensive care; Fever; Antipyretics

Fever improves pathogen control at a significant metabolic cost. No randomized clinical trials (RCT) have compared fever treatment thresholds in critically ill children. We performed a pilot RCT to determine whether a definitive trial of a permissive approach to fever in comparison to current restri...