Latency and reactivation of Marek's disease virus in B lymphocytes transformed by avian leukosis virus

• Published in: Journal of general virology Vol. 74; no. 10; pp. 2163 - 2170
• Main Authors: Fynan, E.F, Ewert, D.L, Block, T.M
• Format: Journal Article
• Language: English
• Published: Reading Soc General Microbiol 01.10.1993; Society for General Microbiology
• Subjects: Alpharetrovirus - physiology; Animals; avian leukosis virus; avian oncovirus; Azacitidine - pharmacology; B-lymphocytes; B-Lymphocytes - microbiology; Biological and medical sciences; cell culture; Cell Line; cell lines; Cell Transformation, Viral - physiology; Chick Embryo; DNA; DNA, Viral - analysis; DNA, Viral - drug effects; Fundamental and applied biological sciences. Psychology; Herpesvirus 2, Gallid - isolation & purification; Herpesvirus 2, Gallid - physiology; lymphocyte proliferation; Mardivirus; Methylation - drug effects; Microbiology; poultry; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Virology; Virus Latency - physiology; Gammaherpesvirinae; Marek disease virus; Oncovirinae; Reactivation; Herpesviridae; Transformed cell; Retroviridae; Virus replication cycle; B-Lymphocyte; Latency; Virus; Type C oncovirus; DNA; Persistent infection; Avian leukosis virus; Methylation; Tumor cell

The physical and biological state of the Marek's disease virus (MDV) genome in avian leukosis virus (ALV)-transformed cells is characterized using cell lines established from ALV tumours co-infected with the SB-1 strain of MDV. The MDV genome within the ALV-transformed cells was found to be met...