Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women

• Published in: European spine journal Vol. 20; no. 4; pp. 572 - 577
• Main Authors: Urano, Tomohiko, Narusawa, Ken’ichiro, Shiraki, Masataka, Sasaki, Noriko, Hosoi, Takayuki, Ouchi, Yasuyoshi, Nakamura, Toshitaka, Inoue, Satoshi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.04.2011; Springer Nature B.V
• Subjects: Aged; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Bone (axial); Cartilage - metabolism; Cartilage diseases; Degeneration; Extracellular matrix; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Gene polymorphism; Genotype; Humans; hyaluronan; Intervertebral Disc Degeneration - ethnology; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - metabolism; Intervertebral discs; Introns; Introns - genetics; Japan; Lumbar Vertebrae - diagnostic imaging; Medicine; Medicine & Public Health; Metabolism; Middle Aged; Neurosurgery; Original; Original Article; Osteoarthritis; osteophytes; Polymerase chain reaction; Polymorphism, Single Nucleotide - genetics; Post-menopause; Proteoglycans; Proteoglycans - genetics; Proteoglycans - metabolism; Radiography; Regression analysis; Risk factors; Sclerosis; Single-nucleotide polymorphism; Spinal Osteophytosis - ethnology; Spinal Osteophytosis - genetics; Spinal Osteophytosis - metabolism; Spine; Surgical Orthopedics; Thoracic Vertebrae - diagnostic imaging; Vertebrae; Cartilage; Single-nucleotide polymorphism (SNP); Disc degeneration; Hyaluronan and proteoglycan link protein gene (HAPLN1); Osteoarthritis

Spinal osteoarthritis including disc degeneration is a very common condition in the axial skeletons of aged people. Recently, spinal osteoarthritis has been shown to be influenced by specific genetic risk factors. Vertebral osteophytes, endplate sclerosis, and intervertebral disc narrowing are recog...