Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women - Urano, Tomohiko; Narusawa, Ken’ichiro; Shiraki, Masataka; Sasaki, Noriko; Hosoi, Takayuki; Ouchi, Yasuyoshi; Nakamura, Toshitaka; Inoue, Satoshi (European spine journal, 2011)
Keywords: Aged; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Bone (axial); Cartilage - metabolism; Cartilage diseases; Degeneration; Extracellular matrix; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Gene polymorphism; Genotype; Humans; hyaluronan; Intervertebral Disc Degeneration - ethnology; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - metabolism; Intervertebral discs; Introns; Introns - genetics; Japan; Lumbar Vertebrae - diagnostic imaging; Medicine; Medicine & Public Health; Metabolism; Middle Aged; Neurosurgery; Original; Original Article; Osteoarthritis; osteophytes; Polymerase chain reaction; Polymorphism, Single Nucleotide - genetics; Post-menopause; Proteoglycans; Proteoglycans - genetics; Proteoglycans - metabolism; Radiography; Regression analysis; Risk factors; Sclerosis; Single-nucleotide polymorphism; Spinal Osteophytosis - ethnology; Spinal Osteophytosis - genetics; Spinal Osteophytosis - metabolism; Spine; Surgical Orthopedics; Thoracic Vertebrae - diagnostic imaging; Vertebrae; Cartilage; Single-nucleotide polymorphism (SNP); Disc degeneration; Hyaluronan and proteoglycan link protein gene (HAPLN1); Osteoarthritis