Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking: A PET/[11C]Raclopride Study in Healthy Men

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 27; no. 6; pp. 1027 - 1035
• Main Authors: Leyton, Marco, Boileau, Isabelle, Benkelfat, Chawki, Diksic, Mirko, Baker, Glen, Dagher, Alain
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2002; Nature Publishing; Nature Publishing Group
• Subjects: Addiction; Adult; Amphetamine - pharmacology; Analysis of Variance; Behavior, Addictive - diagnostic imaging; Behavior, Addictive - metabolism; Biological and medical sciences; Corpus Striatum - diagnostic imaging; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Dopamine - biosynthesis; Exploratory Behavior - drug effects; Exploratory Behavior - physiology; Extracellular Space - diagnostic imaging; Extracellular Space - drug effects; Extracellular Space - metabolism; Humans; Magnetic Resonance Imaging - methods; Male; Medical sciences; Neuropharmacology; Nucleus accumbens; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Raclopride - metabolism; Reinforcement; Reward; Tomography, Emission-Computed - methods; Nucleus accumbens; Reinforcement; Reward; Addiction; Amphetamine derivatives; Human; Dopamine; Healthy subject; CNS stimulant; Psychotropic; Oral administration; Corpus striatum; Personality; Novelty Experiencing Scale; Biological activity; Amfetamine; Positron emission tomography; Brain (vertebrata)

Eight healthy men underwent two positron emission tomography (PET) [11C]raclopride scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, p.o.). PET data were analyzed using: (1) brain parametric maps to statistically generate regions of significant change; and (2) a priori id...