Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives

• Published in: BMC medical research methodology Vol. 16; no. 1; pp. 106 - 7
• Main Authors: Beckett, Robert D., Loeser, Kathryn C., Bowman, Kathryn R., Towne, Trent G.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.08.2016; BioMed Central; BMC
• Subjects: Anti-Infective Agents - therapeutic use; Anti-infectives; Clinical trial evaluation; Cross-Sectional Studies; Disclosure; Humans; Intention to Treat Analysis - methods; Intention-to-treat; Medical research; Medicine; Medicine, Experimental; Methods; Per protocol; Practice; PubMed; Randomized Controlled Trials as Topic - methods; Randomized Controlled Trials as Topic - standards; Research Design - standards; Research Report - standards; Treatment Outcome; Per protocol; Anti-infectives; Clinical trial evaluation; Intention-to-treat

Intention-to-treat (ITT) analysis is commonly recommended for use, due to its benefits on external validity, in randomized, controlled trials (RCTs). No published reports describe how ITT analysis, as well as alternative approaches, are used in anti-infective RCTs. The purpose of this study is to de...