Ticagrelor alleviates pyroptosis of myocardial ischemia reperfusion-induced acute lung injury in rats: a preliminary study

• Published in: PeerJ (San Francisco, CA) Vol. 12; p. e16613
• Main Authors: Dai, Yi-Ning, Wang, Li-Tao, Zhang, Ye-Shen, Xue, Ling, He, Peng-Cheng, Tan, Ning, Liu, Yuan-Hui
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 04.01.2024; PeerJ, Inc; PeerJ Inc
• Subjects: Acute lung injury; Acute Lung Injury - drug therapy; Acute respiratory distress syndrome; Angioplasty; Animals; Antibodies; Apoptosis; Biochemistry; Blood platelets; Caspase 1; Drug approval; Enzyme-linked immunosorbent assay; Eosine Yellowish-(YS); Health aspects; Heart attack; Histology; Humans; Immunohistochemistry; Infection; Infections; Inflammation; Ischemia; Kinases; Leukocytes (neutrophilic); Lung; Lungs; Medical research; Medicine, Experimental; Molecular Biology; Mortality; Myocardial infarction; Myocardial ischemia; Myocardial ischemia-reperfusion injury; Myocardial Reperfusion Injury; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; NLRP3; Pneumonia; Proteins; Pyroptosis; Rats; Rats, Sprague-Dawley; Reperfusion; Respiratory diseases; Surgery; Ticagrelor; Ticagrelor - pharmacology; Transluminal angioplasty; Up-regulation; China; United Kingdom > UK; United States > US; Acute lung injury; NLRP3; Pyroptosis; Ticagrelor; Myocardial ischemia-reperfusion injury

Pulmonary infection is highly prevalent in patients with acute myocardial infarction undergoing percutaneous coronary intervention. However, the potential mechanism is not well characterized. Myocardial ischemia-reperfusion injury (MIRI) induces acute lung injury (ALI) related to pulmonary infection...