A highly elastic tissue sealant based on photopolymerised gelatin

• Published in: Biomaterials Vol. 31; no. 32; pp. 8323 - 8331
• Main Authors: Elvin, Christopher M, Vuocolo, Tony, Brownlee, Alan G, Sando, Lillian, Huson, Mickey G, Liyou, Nancy E, Stockwell, Peter R, Lyons, Russell E, Kim, Misook, Edwards, Glenn A, Johnson, Graham, McFarland, Gail A, Ramshaw, John A.M, Werkmeister, Jerome A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2010
• Subjects: Advanced Basic Science; Animals; Biocompatible Materials - chemistry; Cell Line; Cell Survival; Cross-Linking Reagents - chemistry; Crosslinking; Dentistry; Elasticity; Fishes; Gelatin; Gelatin - chemistry; Gelatin - therapeutic use; Lung - surgery; Lung - ultrastructure; Mice; Photochemical Processes; Photopolymerisation; Polymerization; Sheep; Swine; Tensile Strength; Tissue Adhesives - chemistry; Tissue Adhesives - therapeutic use; Tissue sealant; Elasticity; Crosslinking; Photopolymerisation; Tissue sealant; Gelatin

Abstract Gelatin is widely used as a medical biomaterial because it is readily available, cheap, biodegradable and demonstrates favourable biocompatibility. Many applications require stabilisation of the biomaterial by chemical crosslinking, and this often involves derivatisation of the protein or t...