Nanostructured electrochemical biosensor for th0065 detection of the weak binding between the dengue virus and the CLEC5A receptor

• Published in: Nanomedicine Vol. 10; no. 6; pp. 1335 - 1341
• Main Authors: Tung, Yen-Ting, Wu, Ming-Fang, Wang, Gou-Jen, Hsieh, Shie-Liang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2014
• Subjects: Anodic aluminum oxide; Biosensing Techniques - instrumentation; CLEC5A; Dengue - metabolism; Dengue virus; Dengue Virus - metabolism; Dielectric Spectroscopy - instrumentation; Electrochemical impedance spectroscopy; Electrodes; Equipment Design; Gold - chemistry; Humans; Internal Medicine; Lectins, C-Type - metabolism; Nanostructured biosensor; Nanostructures - chemistry; Nanostructures - ultrastructure; Protein Binding; Receptors, Cell Surface - metabolism; Anodic aluminum oxide; Nanostructured biosensor; Dengue virus; CLEC5A; Electrochemical impedance spectroscopy

In this paper, we develop an effective method for detecting weak molecular bonding between the dengue virus (DV) and its receptor C-type lectin domain family 5, member A (CLEC5A). The CLEC5A–DV interaction is critical for DV-induced hemorrhagic fever and shock syndrome, so the sensing of CLEC5A–DV b...