Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Depression

• Published in: The New England journal of medicine Vol. 356; no. 17; pp. 1711 - 1722
• Main Authors: Sachs, Gary S, Nierenberg, Andrew A, Calabrese, Joseph R, Marangell, Lauren B, Wisniewski, Stephen R, Gyulai, Laszlo, Friedman, Edward S, Bowden, Charles L, Fossey, Mark D, Ostacher, Michael J, Ketter, Terence A, Patel, Jayendra, Hauser, Peter, Rapport, Daniel, Martinez, James M, Allen, Michael H, Miklowitz, David J, Otto, Michael W, Dennehy, Ellen B, Thase, Michael E
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 26.04.2007
• Subjects: Adult; Antidepressants; Antidepressive Agents, Second-Generation - adverse effects; Antidepressive Agents, Second-Generation - therapeutic use; Antimanic Agents - adverse effects; Antimanic Agents - therapeutic use; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - drug therapy; Bupropion - therapeutic use; Clinical medicine; Double-Blind Method; Drug Therapy, Combination; FDA approval; Female; General aspects; Humans; Male; Medical sciences; Mental depression; Neuropharmacology; Paroxetine - therapeutic use; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Regulatory approval; Studies; Treatment Outcome; Mood disorder; Medicine; Depressions; Efficiency; Psychotropic; Antidepressant agent; Depression

The risks and benefits of standard antidepressants for patients with bipolar disorder are not well understood. In this randomized, placebo-controlled trial of patients with bipolar disorder, all of whom received a mood stabilizer, adjunctive treatment with an antidepressant did not reduce the sympto...