Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer

• Published in: Journal of international medical research Vol. 49; no. 5; p. 3000605211012570
• Main Authors: Huang, Xiwen, Lan, Yongquan, Li, En, Li, Jiaquan, Deng, Qiaoting, Deng, Xunwei
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Antigens; Biomarkers; Biomarkers, Tumor; CA-19-9 Antigen; Carcinoembryonic Antigen; Colorectal cancer; Colorectal Neoplasms - diagnosis; Humans; Matrix Metalloproteinase 11; Matrix Metalloproteinase 7; Matrix Metalloproteinase 9; Prognosis; Retrospective Clinical Research Report; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; carcinoembryonic antigen; Colorectal cancer; matrix metalloproteinase-7; combined detection; tissue inhibitor of metalloproteinase-1; diagnosis; biomarker
• DOI: 10.1177/03000605211012570
• ISSN: 0300-0605; 1473-2300

Objective Colorectal cancer (CRC) is one of the most common and lethal malignancies. The identification of precise and noninvasive biomarkers is urgently needed to aid the early diagnosis and clinical management of CRC. Methods A total of 112 patients with CRC and 115 healthy control subjects were included in this study. Serum levels of matrix metalloproteinase (MMP)-7, MMP-9, MMP-11, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 were analyzed by enzyme-linked immunosorbent assay, and carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19-9 levels were measured using an automatic immunoassay analyzer. Results MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 levels were all significantly higher in CRC patients compared with healthy controls. MMP-7, TIMP-1, and CEA levels were also closely related to clinicopathologic features in patients with CRC. The combination of serum CEA, MMP-7, and TIMP-1 significantly improved the diagnostic value compared with any single marker (area under the curve 0.858–0.890). Furthermore, a combined detection model including MMP-7, TIMP-1, and CEA improved both the specificity and sensitivity for detecting CRC. Conclusions The results showed that combined detection of CEA, MMP-7, and TIMP-1 in serum could provide a specific and sensitive biomarker for the diagnosis of CRC.